2017
The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family
Sun N, Nasello C, Deng L, Wang N, Zhang Y, Xu Z, Song Z, Kwan K, King R, Pang Z, Xing J, Heiman G, Tischfield J. The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. Molecular Psychiatry 2017, 23: 1487-1495. PMID: 28894297, PMCID: PMC5847395, DOI: 10.1038/mp.2017.179.Peer-Reviewed Original ResearchConceptsNonsense-mediated mRNA decayNonsense mutationMultiplex familiesPluripotent stem cellsTD phenotypeDeleterious sequence variantsGenetic architectureMRNA decayHouse bioinformatics pipelineDNA sequencesBioinformatics pipelineTD familyWhole-exome sequencingSequence variantsBiochemical assaysMolecular differencesWhole exomeIsoform levelsStem cellsProtein levelsTD etiologyExome sequencingPNKDHeterozygous nonsense mutationGenes
2005
Regarding “Antibiotic Prophylaxis with Azithromycin or Penicillin for Childhood-Onset Neuropsychiatric Disorders”
Group T, Budman C, Coffey B, Dure L, Gilbert D, Juncos J, Kaplan E, King R, Kurlan R, Lowe T, Mack K, Mink J, Schlaggar B, Singer H. Regarding “Antibiotic Prophylaxis with Azithromycin or Penicillin for Childhood-Onset Neuropsychiatric Disorders”. Biological Psychiatry 2005, 58: 917. PMID: 16242121, DOI: 10.1016/j.biopsych.2005.08.005.Peer-Reviewed Original Research
2001
Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders
Morshed S, Parveen S, Leckman J, Mercadante M, Kiss M, Miguel E, Arman A, Yazgan Y, Fujii T, Paul S, Peterson B, Zhang H, King R, Scahill L, Lombroso P. Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders. Biological Psychiatry 2001, 50: 566-577. PMID: 11690591, DOI: 10.1016/s0006-3223(01)01096-4.Peer-Reviewed Original ResearchConceptsTotal antinuclear antibodiesAntinuclear antibodiesAutoimmune disordersTourette syndromeAnticytoskeletal antibodiesAntineural antibodiesStreptococcal infectionT patientsTS patientsBeta-hemolytic streptococcal infectionPrior streptococcal infectionHemolytic streptococcal infectionAntistreptolysin O titerIndirect immunofluorescent assayLevels of immunoreactivityWestern blot techniqueMean rankClinical characteristicsSydenham's choreaO titerPatient groupSC patientsIgG antibodiesIgG classNormal controlsPsychosocial and Risk Behavior Correlates of Youth Suicide Attempts and Suicidal Ideation
KING R, SCHWAB-STONE M, FLISHER A, GREENWALD S, KRAMER R, GOODMAN S, LAHEY B, SHAFFER D, GOULD M. Psychosocial and Risk Behavior Correlates of Youth Suicide Attempts and Suicidal Ideation. Journal Of The American Academy Of Child & Adolescent Psychiatry 2001, 40: 837-846. PMID: 11437023, DOI: 10.1097/00004583-200107000-00019.Peer-Reviewed Original ResearchConceptsSuicidal ideationRisk behavior correlatesStressful life eventsCurrent smokingLow parental monitoringAdolescent Mental Disorders (MECA) StudySignificant associationRisk behaviorsPoor family environmentEpidemiology of ChildParental psychiatric historySexual activityMental Disorders StudyLife eventsNIMH MethodsPsychiatric historyPsychiatric disordersDisruptive disordersPhysical fightingBehavior correlatesSociodemographic characteristicsSuicide attemptsFamily environmentSociodemographic variablesSubject characteristicsAre child-, adolescent-, and adult-onset depression one and the same disorder?
Kaufman J, Martin A, King R, Charney D. Are child-, adolescent-, and adult-onset depression one and the same disorder? Biological Psychiatry 2001, 49: 980-1001. PMID: 11430841, DOI: 10.1016/s0006-3223(01)01127-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-Inflammatory AgentsAntidepressive Agents, TricyclicBrainChildCorticotropin-Releasing HormoneDepressive Disorder, MajorDexamethasoneDiagnosis, DifferentialGrowth Hormone-Releasing HormoneHumansHydrocortisoneImmunity, CellularMagnetic Resonance ImagingSerotoninThyroid HormonesConceptsAdult-onset depressionBasal cortisol secretionStage of illnessSerotonergic probeTricyclic medicationDepressed cohortClinical outcomesCortisol secretionHormone infusionIllness factorsTreatment responsePreclinical studiesSame disorderDepressed adultsImmunity indicesDepression oneFamilial subtypeNeurobiological assessmentNeurobiological correlatesChildrenAdolescentsIllnessDiscrepant findingsNeuroimaging paradigmDepression
2000
Risk Behavior in a Community Sample of Children and Adolescents
FLISHER A, KRAMER R, HOVEN C, KING R, BIRD H, DAVIES M, GOULD M, GREENWALD S, LAHEY B, REGIER D, SCHWAB-STONE M, SHAFFER D. Risk Behavior in a Community Sample of Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 881-887. PMID: 10892230, DOI: 10.1097/00004583-200007000-00017.Peer-Reviewed Original ResearchConceptsRisk behaviorsFunctional impairmentAdolescent Mental Disorders (MECA) StudyFamily psychiatric disordersEpidemiology of ChildMental Disorders StudySuicidal ideation/attemptsPotential correlatesCigarette smokingOdds ratioCommunity probability sampleMarijuana smokingPsychiatric disordersLinear regression analysisAlcohol useDisorders StudySmokingRegression analysisChildrenCommunity sampleProbability sampleAdolescentsImpairmentPsychopathologySignificant relationshipPharmacologic Treatment of Tic Disorders
Scahill L, Chappell P, King R, Leckman J. Pharmacologic Treatment of Tic Disorders. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 99-117. PMID: 10674192, DOI: 10.1016/s1056-4993(18)30137-8.Peer-Reviewed Original ResearchConceptsTic disordersTreatment of ADHDAtypical neurolepticsLong-term side effectsNewer atypical neurolepticsFirst-line treatmentTreatment of ticsBotulinum toxin injectionMore studiesUse of stimulantsNonstimulant medicationsToxin injectionPharmacologic treatmentPsychiatric comorbidityStandard treatmentTraditional neurolepticsTarget symptomsSide effectsStimulant medicationMedicationsNeurolepticsAdverse effectsComorbid ADHDDisordersTreatment planning
1998
Psychopathology Associated With Suicidal Ideation and Attempts Among Children and Adolescents
GOULD M, KING R, GREENWALD S, FISHER P, SCHWAB-STONE M, KRAMER R, FLISHER A, GOODMAN S, CANINO G, SHAFFER D. Psychopathology Associated With Suicidal Ideation and Attempts Among Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 915-923. PMID: 9735611, DOI: 10.1097/00004583-199809000-00011.Peer-Reviewed Original ResearchConceptsSubstance abuse/dependenceAbuse/dependenceSuicidal ideationSuicide attemptsPsychiatric disordersSubstance abuse/dependence disordersAdolescent Mental Disorders (MECA) StudySuicide riskNoncriterion symptomsChildren Version 2.3Epidemiology of ChildAge-specific riskDiagnostic Interview ScheduleMental Disorders StudyLogistic regression analysisDependence disordersDisruptive disordersPanic attacksSignificant independent contributionSociodemographic characteristicsRisk profileSuicidal thoughtsSpecific disordersSuicide attemptersSymptom correlatesSTIMULANT USE AND TRICHOTILLOMANIA
Martin A, Scahill L, Vitulano L, King R. STIMULANT USE AND TRICHOTILLOMANIA. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 349-350. PMID: 9549952, DOI: 10.1097/00004583-199804000-00009.Peer-Reviewed Original Research
1997
Children's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity
Scahill L, Riddle M, McSwiggin-Hardin M, Ort S, King R, Goodman W, Cicchetti D, Leckman J. Children's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity. Journal Of The American Academy Of Child & Adolescent Psychiatry 1997, 36: 844-852. PMID: 9183141, DOI: 10.1097/00004583-199706000-00023.Peer-Reviewed Original ResearchConceptsChildren's Yale-Brown Obsessive Compulsive ScaleYale-Brown Obsessive Compulsive ScaleObsessive-compulsive disorderObsessive-compulsive symptom severityManifest Anxiety ScaleObsessive-compulsive symptomsObsessive Compulsive ScaleChildren's Manifest Anxiety ScaleCompulsive ScaleCY-BOCS total scoreSymptom severityDepression InventoryChildren's Depression InventoryTotal scoreCY-BOCS scoresAnxiety ScaleConvergent validityValid subscalesInternal consistencyCompulsion scoreAdolescentsSubscalesChildrenInterrater agreementValidityRitual, Habit, and Perfectionism: The Prevalence and Development of Compulsive‐like Behavior in Normal Young Children
Evans D, Leckman J, Carter A, Reznick J, Henshaw D, King R, Pauls D. Ritual, Habit, and Perfectionism: The Prevalence and Development of Compulsive‐like Behavior in Normal Young Children. Child Development 1997, 68: 58-68. PMID: 9084125, DOI: 10.1111/j.1467-8624.1997.tb01925.x.Peer-Reviewed Original Research
1996
A Putative Poststreptococcal Case of OCD with Chronic Tic Disorder, Not Otherwise Specified
TUCKER D, LECKMAN J, SCAHILL L, WILF G, LaCAMERA R, CARDONA L, COHEN P, HEIDMANN S, GOLDSTEIN J, JUDGE J, SNYDER E, BULT A, PETERSON B, KING R, LOMBROSO P. A Putative Poststreptococcal Case of OCD with Chronic Tic Disorder, Not Otherwise Specified. Journal Of The American Academy Of Child & Adolescent Psychiatry 1996, 35: 1684-1691. PMID: 8973076, DOI: 10.1097/00004583-199612000-00022.Peer-Reviewed Original ResearchConceptsChronic tic disorderTic disordersSelective serotonin reuptake inhibitorsSessions of plasmapheresisSerotonin reuptake inhibitorsUpper respiratory symptomsTreatment-resistant casesClinical laboratory dataCognitive behavioral therapyNeuroimmunological perspectiveProphylactic penicillinRespiratory symptomsReuptake inhibitorsObsessive-compulsive disorderConventional pharmacotherapyTreatment optionsSupportive psychotherapyFamily interventionsSeparation anxietyLaboratory dataSubsequent treatmentDisordersPsychotherapyMultiple perspectivesPharmacotherapyBehavioral Therapy in Children and Adolescents with Obsessive-Compulsive Disorder: A Pilot Study
Scahill L, Vitulano L, Brenner E, Lynch K, King R. Behavioral Therapy in Children and Adolescents with Obsessive-Compulsive Disorder: A Pilot Study. Journal Of Child And Adolescent Psychopharmacology 1996, 6: 191-202. PMID: 9231312, DOI: 10.1089/cap.1996.6.191.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleBehavioral treatmentBehavioral therapyRandomized clinical trialsTreatment of childrenChildren's Yale-Brown Obsessive Compulsive ScaleBehavioral therapy programObsessive Compulsive ScaleMedication treatmentPrimary diagnosisMonths posttreatmentClinical trialsTreatment endpointBooster sessionsDose reductionDose requirementsMedicationsUseful adjunctTherapeutic gainTreatment programTherapy programPilot studyCompulsive ScaleTreatment
1995
Childhood Trichotillomania: Clinical Phenomenology, Comorbidity, and Family Genetics
KING R, SCAHILL L, VITULANO L, SCHWAB-STONE M, TERCYAK K, RIDDLE M. Childhood Trichotillomania: Clinical Phenomenology, Comorbidity, and Family Genetics. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1451-1459. PMID: 8543512, DOI: 10.1097/00004583-199511000-00011.Peer-Reviewed Original ResearchRisperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report
LOMBROSO P, SCAHILL L, KING R, LYNCH K, CHAPPELL P, PETERSON B, McDOUGLE C, LECKMAN J. Risperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1147-1152. PMID: 7559308, DOI: 10.1097/00004583-199509000-00011.Peer-Reviewed Original ResearchConceptsChronic tic disorderTic disordersObsessive-compulsive disorderChronic motor tic disorderYale Global Tic Severity ScaleDopamine-blocking propertiesOpen-label trialFrequent side effectsEfficacy of risperidoneMotor tic disorderShort-term safetyTic Severity ScaleComorbid obsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleClinical responseRisperidone treatmentMean ageTic scoreSeverity ScaleSide effectsTourette syndromeComorbid diagnosesTic frequencyWeight gain
1992
Double-Blind, Crossover Trial of Fluoxetine and Placebo in Children and Adolescents with Obsessive-Compulsive Disorder
RIDDLE M, SCAHILL L, KING R, HARDIN M, ANDERSON G, ORT S, SMITH J, LECKMAN J, COHEN D. Double-Blind, Crossover Trial of Fluoxetine and Placebo in Children and Adolescents with Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 1992, 31: 1062-1069. PMID: 1429406, DOI: 10.1097/00004583-199211000-00011.Peer-Reviewed Original ResearchConceptsChildren's Yale-Brown Obsessive Compulsive ScaleObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleEffective short-term treatmentSafety of fluoxetineFixed-dose trialCommon drug side effectsCY-BOCS total scoreMajor depressive disorderShort-term treatmentDrug side effectsMagnitude of improvementObsessive Compulsive ScaleFluoxetine groupPlacebo groupFluoxetine treatmentCrossover trialClinical trialsDepressive disorderObsessive-compulsive symptom severitySide effectsFluoxetineSymptom severityTotal scoreCompulsive ScaleBehavioral Treatment of Children and Adolescents with Trichotillomania
VITULANO L, KING R, SCAHILL L, COHEN D. Behavioral Treatment of Children and Adolescents with Trichotillomania. Journal Of The American Academy Of Child & Adolescent Psychiatry 1992, 31: 139-146. PMID: 1537765, DOI: 10.1097/00004583-199201000-00021.Peer-Reviewed Original ResearchConceptsStandard psychiatric careBehavioral treatment programTreatment modalitiesPsychiatric careBehavior disorderBehavioral treatmentTreatment programPilot findingsRelative safetyTrichotillomaniaBehavioral techniquesPotential effectivenessChildrenAdolescentsUseful rolePatientsPharmacologicalDisfigurementScalpCare
1991
Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment
KING R, RIDDLE M, CHAPPELL P, HARDIN M, ANDERSON G, LOMBROSO P, SCAHILL L. Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment. Journal Of The American Academy Of Child & Adolescent Psychiatry 1991, 30: 179-186. PMID: 2016219, DOI: 10.1097/00004583-199103000-00003.Peer-Reviewed Original ResearchConceptsFluoxetine treatmentObsessive-compulsive disorderUniversity Clinical Research CenterClinical Research CenterMajor risk factorDrug-induced activationPrior suicidal ideationYounger patientsRisk factorsRegulation of aggressionPatientsSuicidal ideationSelf-destructive behaviorFluoxetineAge 10Apparent associationVulnerable individualsDisordersTreatmentIdeationDe novoHospitalizationSymptomsSudden Death in Children Receiving Norpramin®: A Review of Three Reported Cases and Commentary
RIDDLE M, NELSON J, KLEINMAN C, RASMUSSON A, LECKMAN J, KING R, COHEN D. Sudden Death in Children Receiving Norpramin®: A Review of Three Reported Cases and Commentary. Journal Of The American Academy Of Child & Adolescent Psychiatry 1991, 30: 104-108. PMID: 2005044, DOI: 10.1097/00004583-199101000-00016.Peer-Reviewed Original Research
1990
Obsessive Compulsive Disorder in Children and Adolescents: Phenomenology and Family History
RIDDLE M, SCAHILL L, KING R, HARDIN M, TOWBIN K, ORT S, LECKMAN J, COHEN D. Obsessive Compulsive Disorder in Children and Adolescents: Phenomenology and Family History. Journal Of The American Academy Of Child & Adolescent Psychiatry 1990, 29: 766-772. PMID: 2228931, DOI: 10.1097/00004583-199009000-00015.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCompulsive disorderDisorder diagnosisAnxiety disorder diagnosisObsessive-compulsive symptomsClinical psychiatric assessmentMood disorder diagnosisAssociated psychopathologyContamination concernsResearch implicationsAdolescentsPsychiatric assessmentChildrenDisordersFamily membersPsychopathologyPhenomenologyParentsSymptomsImplicationsFindingsFamily historyBehavior