2004
Dietary acid, endothelins, and sleep.
Alpern RJ, Preisig PA. Dietary acid, endothelins, and sleep. Transactions Of The American Clinical And Climatological Association 2004, 115: 385-93; discussion 393-4. PMID: 17060981, PMCID: PMC2263788.Peer-Reviewed Original ResearchConceptsTrafficking of NHE3Proximal tubule cell lineNHE3 activityTubule cell lineSecond intracellular loopEndothelin expressionDietary acidNHE3 abundanceActivation of NHE3OKP cellsProximal tubulesNHE3 mRNAApical membraneHomeostatic responseProtein expressionC-fosReceptor specificityIntracellular loopReceptorsEndothelinCell linesC-JunNHE3C-SrcAcid signaling
1991
Increased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy.
Preisig PA, Alpern RJ. Increased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy. The Journal Of General Physiology 1991, 97: 195-217. PMID: 1849958, PMCID: PMC2216475, DOI: 10.1085/jgp.97.2.195.Peer-Reviewed Original ResearchConceptsHyperfiltration groupChronic hyperfiltrationNa/H antiporterKidney weightCell hypertrophyHigher glomerular filtration rateNa/H antiporter activityH antiporterGlomerular filtration rateVivo microperfused rat proximal tubuleCell pHRat proximal tubuleSymporter activityFiltration rateProximal tubulesUltrafiltrate-like solutionHyperfiltrationSteady-state cell pHProtein feedingPeritubular perfusateDietary proteinParallel increaseUninephrectomyHypertrophyCell acidification
1990
Cellular model of proximal tubule NaCl and NaHCO3 absorption
Moe O, Preisig P, Alpern R. Cellular model of proximal tubule NaCl and NaHCO3 absorption. Kidney International 1990, 38: 605-611. PMID: 2172616, DOI: 10.1038/ki.1990.249.Peer-Reviewed Original Research
1988
Hepatic renal interrelations in acid-base regulation
Alpern RJ, Star R, Seldin DW. Hepatic renal interrelations in acid-base regulation. American Journal Of Physiology 1988, 255: f807-f809. PMID: 3177661, DOI: 10.1152/ajprenal.1988.255.4.f807.Peer-Reviewed Original Research
1987
Kinetic transport model for cellular regulation of pH and solute concentration in the renal proximal tubule
Verkman AS, Alpern RJ. Kinetic transport model for cellular regulation of pH and solute concentration in the renal proximal tubule. Biophysical Journal 1987, 51: 533-546. PMID: 3580482, PMCID: PMC1329926, DOI: 10.1016/s0006-3495(87)83379-9.Peer-Reviewed Original Research
1985
A model of proximal tubular bicarbonate absorption
Alpern RJ, Rector FC. A model of proximal tubular bicarbonate absorption. American Journal Of Physiology 1985, 248: f272-f281. PMID: 3970216, DOI: 10.1152/ajprenal.1985.248.2.f272.Peer-Reviewed Original Research
1983
Flow dependence of proximal tubular bicarbonate absorption
Alpern RJ, Cogan MG, Rector FC. Flow dependence of proximal tubular bicarbonate absorption. American Journal Of Physiology 1983, 245: f478-f484. PMID: 6414312, DOI: 10.1152/ajprenal.1983.245.4.f478.Peer-Reviewed Original ResearchConceptsLuminal bicarbonate concentrationBicarbonate absorptionFlow-dependent increaseFlow-dependent decreaseProximal convoluted tubulesBicarbonate concentrationFlow-induced increaseFlow-dependent changesConvoluted tubulesX minPmol xStimulationProton secretionTubulesPerfusion rateMaximal rateObserved stimulationMin