1993
The renal proximal tubule renin-angiotensin system.
Moe O, Alpern R, Henrich W. The renal proximal tubule renin-angiotensin system. Seminars In Nephrology 1993, 13: 552-7. PMID: 8278688.Peer-Reviewed Original ResearchConceptsProximal tubule renin-angiotensin systemProximal tubulesRenin-angiotensin systemAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseasePolycystic kidney diseaseEssential hypertensionKidney diseasePathogenetic roleRenal vasculatureJG cellsCyst growthMammalian proximal tubuleHypertensionReninTubulesComplete RASPatientsDiseaseAutocrineParacrineRAVasculature
1991
Regulation of proximal reabsorption by effective arterial blood volume.
Seldin DW, Preisig PA, Alpern RJ. Regulation of proximal reabsorption by effective arterial blood volume. Seminars In Nephrology 1991, 11: 212-9. PMID: 2034926.Peer-Reviewed Original ResearchConceptsEffective arterial blood volumeEffective arterial volumeRenal nerve activityProximal tubular transportAtrial natriuretic factorArterial blood volumeLevels of hormonesRenal hemodynamicsNerve activityDietary NaClAngiotensin IIProximal reabsorptionNatriuretic factorBlood volumeTubular transportProximal tubulesChronic effectsArterial volumeOncotic pressureNorepinephrineHemodynamicsEpinephrineHormoneReabsorptionDietary NaCl modulates Na(+)-H+ antiporter activity in renal cortical apical membrane vesicles
Moe OW, Tejedor A, Levi M, Seldin DW, Preisig PA, Alpern RJ. Dietary NaCl modulates Na(+)-H+ antiporter activity in renal cortical apical membrane vesicles. American Journal Of Physiology 1991, 260: f130-f137. PMID: 1847012, DOI: 10.1152/ajprenal.1991.260.1.f130.Peer-Reviewed Original ResearchConceptsDietary NaClNaCl reabsorptionSystemic acid-base disturbancesExtracellular fluid volume depletionNaHCO3 reabsorptionExtracellular fluid volume expansionFluid volume depletionHigh-salt dietChronic metabolic alkalosisFluid volume expansionAcridine orange fluorescence methodExtracellular fluid volumeAcid-base disturbancesAntiporter activityDietary protocolChronic alterationsVolume depletionMetabolic alkalosisChronic changesHS dietApical membrane vesiclesLS dietFluid volumeRatsReabsorption
1990
Cellular model of proximal tubule NaCl and NaHCO3 absorption
Moe O, Preisig P, Alpern R. Cellular model of proximal tubule NaCl and NaHCO3 absorption. Kidney International 1990, 38: 605-611. PMID: 2172616, DOI: 10.1038/ki.1990.249.Peer-Reviewed Original Research
1989
Contributions of cellular leak pathways to net NaHCO3 and NaCl absorption.
Preisig PA, Alpern RJ. Contributions of cellular leak pathways to net NaHCO3 and NaCl absorption. Journal Of Clinical Investigation 1989, 83: 1859-1867. PMID: 2542374, PMCID: PMC303906, DOI: 10.1172/jci114092.Peer-Reviewed Original Research
1986
Evidence for electroneutral sodium chloride transport in rat proximal convoluted tubule
Howlin KJ, Alpern RJ, Berry CA, Rector FC. Evidence for electroneutral sodium chloride transport in rat proximal convoluted tubule. American Journal Of Physiology 1986, 250: f644-f648. PMID: 3963204, DOI: 10.1152/ajprenal.1986.250.4.f644.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCyanidesElectrophysiologyKidney Tubules, ProximalMaleMembrane PotentialsRatsSodium ChlorideConceptsTransepithelial potential differenceLate proximal tubular fluidProximal tubular fluidNaCl transportEffect of cyanideLumen-negative potential differenceSodium chloride transportLuminal perfusateTubular fluidNaCl absorptionTwo-thirdsTubulesPotential differenceChloride transportActive transportPerfusate
1985
Amiloride inhibition of proximal tubular acidification
Howlin KJ, Alpern RJ, Rector FC. Amiloride inhibition of proximal tubular acidification. American Journal Of Physiology 1985, 248: f773-f778. PMID: 2988347, DOI: 10.1152/ajprenal.1985.248.6.f773.Peer-Reviewed Original ResearchConceptsProximal tubular acidificationLuminal amilorideBicarbonate absorptionX minTubular acidificationM amilorideSodium chloride absorptionLate proximal tubular fluidProximal tubular fluidPerfusion rateProximal acidificationVivo microperfusionTubular fluidKidney cortexChloride absorptionInhibition of acidificationPmol xAmilorideNonspecific inhibitionAmiloride inhibitionGreater inhibitionBrush border membrane vesiclesInhibitionGlucose effluxPotent inhibitor