Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons
Rajebhosale P, Ananth M, Kim R, Crouse R, Jiang L, López-Hernández G, Zhong C, Arty C, Wang S, Jone A, Desai N, Li Y, Picciotto M, Role L, Talmage D. Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons. ELife 2024, 13: e86581. PMID: 38363713, PMCID: PMC10928508, DOI: 10.7554/elife.86581.Peer-Reviewed Original ResearchBasolateral amygdalaCholinergic neuronsThreatening stimuliMemory recallPredator odorDefensive behaviorResponse to predator odorBasal forebrain cholinergic projection neuronsBasal forebrain of micePosterior substantia innominataForebrain of miceSource of cholinergic inputCholinergic basal forebrainIncreased intrinsic excitabilityCholinergic projection neuronsThreat memoryFoot shockAversive stimuliChemogenetic silencingCholinergic inputSubstantia innominataPopulation of cholinergic neuronsNucleus basalisIntrinsic excitabilityProjection neurons