2024
Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons
Rajebhosale P, Ananth M, Kim R, Crouse R, Jiang L, López-Hernández G, Zhong C, Arty C, Wang S, Jone A, Desai N, Li Y, Picciotto M, Role L, Talmage D. Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons. ELife 2024, 13: e86581. PMID: 38363713, PMCID: PMC10928508, DOI: 10.7554/elife.86581.Peer-Reviewed Original ResearchBasolateral amygdalaCholinergic neuronsThreatening stimuliMemory recallPredator odorDefensive behaviorResponse to predator odorBasal forebrain cholinergic projection neuronsBasal forebrain of micePosterior substantia innominataForebrain of miceSource of cholinergic inputCholinergic basal forebrainIncreased intrinsic excitabilityCholinergic projection neuronsThreat memoryFoot shockAversive stimuliChemogenetic silencingCholinergic inputSubstantia innominataPopulation of cholinergic neuronsNucleus basalisIntrinsic excitabilityProjection neurons
2020
Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency
Crouse RB, Kim K, Batchelor HM, Girardi EM, Kamaletdinova R, Chan J, Rajebhosale P, Pittenger ST, Role LW, Talmage DA, Jing M, Li Y, Gao XB, Mineur YS, Picciotto MR. Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency. ELife 2020, 9: e57335. PMID: 32945260, PMCID: PMC7529459, DOI: 10.7554/elife.57335.Peer-Reviewed Original ResearchConceptsBasolateral amygdalaCue-reward learningActivity of neuronsReward-related eventsNucleus basalisBLA responsesACh levelsPredictors of rewardTerminal fibersNeuron activityReward-predictive cuesCalcium indicatorsAChNeutral cuesEmotional stimuliAversive stimuliReward retrievalTask acquisitionAmygdalaSalient eventsMiceACh sensorTerminal activityQuick acquisitionCues