2023
The Impact of Rapid Drug Susceptibility Tests on Gonorrhea Burden and the Life Span of Antibiotic Treatments: A Modeling Study Among Men Who Have Sex With Men in the United States
Yaesoubi R, Xi Q, Hsu K, Gift T, St. Cyr S, Rönn M, Salomon J, Grad Y. The Impact of Rapid Drug Susceptibility Tests on Gonorrhea Burden and the Life Span of Antibiotic Treatments: A Modeling Study Among Men Who Have Sex With Men in the United States. American Journal Of Epidemiology 2023, 193: 17-25. PMID: 37625444, PMCID: PMC10773484, DOI: 10.1093/aje/kwad175.Peer-Reviewed Original ResearchConceptsRapid drug susceptibility testDrug susceptibility testGonorrhea casesSusceptibility testsFirst-line treatmentBurden of gonorrheaGonococcal infectionGonorrhoea transmissionAntibiotic treatmentPatient outcomesIndividualized treatmentLife spanDrug susceptibilityCare testRapid pointEffective life spanAntibiotic resistanceAntibioticsTest specificityGonorrheaMenCiprofloxacinTreatmentCorrect ascertainmentLong-term impact
2022
Evaluating spatially adaptive guidelines for the treatment of gonorrhea to reduce the incidence of gonococcal infection and increase the effective lifespan of antibiotics
Yaesoubi R, Cohen T, Hsu K, Gift TL, St. Cyr SB, Salomon JA, Grad YH. Evaluating spatially adaptive guidelines for the treatment of gonorrhea to reduce the incidence of gonococcal infection and increase the effective lifespan of antibiotics. PLOS Computational Biology 2022, 18: e1009842. PMID: 35139073, PMCID: PMC8863219, DOI: 10.1371/journal.pcbi.1009842.Peer-Reviewed Original ResearchConceptsIncidence of gonorrhoeaTreatment guidelinesResistance prevalenceGonorrhea casesTreatment of gonorrheaNational surveillance systemPrevalence of resistanceTransmission dynamic modelGonococcal infectionGonorrhea treatmentMSM populationAntibiotic susceptibilityGonorrheaStandardized guidelinesSurveillance dataPrevalenceIncidenceAntibioticsPotential strategySurveillance systemAbsence of pointsGuidelinesCurrent strategiesEffective lifespanMen
2020
Adaptive guidelines for the treatment of gonorrhea to increase the effective life span of antibiotics among men who have sex with men in the United States: A mathematical modeling study
Yaesoubi R, Cohen T, Hsu K, Gift TL, Chesson H, Salomon JA, Grad YH. Adaptive guidelines for the treatment of gonorrhea to increase the effective life span of antibiotics among men who have sex with men in the United States: A mathematical modeling study. PLOS Medicine 2020, 17: e1003077. PMID: 32243443, PMCID: PMC7122693, DOI: 10.1371/journal.pmed.1003077.Peer-Reviewed Original ResearchConceptsFirst-line antibioticsPrevalence of resistanceMSM populationGonorrhea casesPrevalence of gonorrheaTreatment of gonorrheaTransmission of gonorrheaIncidence of gonorrhoeaGonococcal antimicrobial resistanceProportion of casesAlternative surveillance strategiesBurden of gonorrheaEffective surveillance systemTreatment guidelinesGonorrhea treatmentGonorrhoea transmissionClinical effectivenessOverall burdenSurveillance estimatesLife spanGonorrheaDrug susceptibilitySurveillance findingsSurveillance strategiesSurveillance program