2020
17β-estradiol attenuates rat articular chondrocyte injury by targeting ASIC1a-mediated apoptosis
Song S, Tao J, Li S, Qian X, Niu R, Wang C, Zhang Y, Chen Y, Wang K, Zhu F, Zhu C, Ma G, Yang-Yang, Peng X, Zhou R, Chen F. 17β-estradiol attenuates rat articular chondrocyte injury by targeting ASIC1a-mediated apoptosis. Molecular And Cellular Endocrinology 2020, 505: 110742. PMID: 32006608, DOI: 10.1016/j.mce.2020.110742.Peer-Reviewed Original ResearchConceptsAcid-sensing ion channel 1aRheumatoid arthritisChondrocyte injuryTreatment of RAEstradiol replacement therapyProtein levelsAcid-induced damageIon channel 1aAutophagy-lysosomal pathwayJoint swellingCartilage destructionLocal inflammationOvariectomized modelReplacement therapyEstrogen metabolismArticular damageEpidemiological evidenceASIC1a proteinProtective roleAcid-induced apoptosisChannel 1aSodium-permeable channelsInjuryERα receptorMitochondrial function
2019
β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation
Zhou R, Leng T, Yang T, Chen F, Hu W, Xiong Z. β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation. Stroke 2019, 50: 2902-2911. PMID: 31412757, PMCID: PMC6756944, DOI: 10.1161/strokeaha.119.025940.Peer-Reviewed Original ResearchConceptsIschemic neuronal injuryIschemic brain injuryΒ-estradiol treatmentASIC1a protein expressionNeuronal injuryASIC currentsBrain injuryProtein expressionΒ-estradiolWhole-cell patch-clamp techniqueIntracellular CaAcidosis-induced cytotoxicityAcidosis-mediated injuryActivation of ASIC1aDegree of neuroprotectionOutcome of strokeSeverity of strokeMiddle cerebral arteryTransient focal ischemiaOnline visual overviewAcid-induced elevationEstrogen receptor αReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionPatch-clamp technique