2021
Curcumin ameliorates IL‐1β‐induced apoptosis by activating autophagy and inhibiting the NF‐κB signaling pathway in rat primary articular chondrocytes
Chen T, Zhou R, Chen Y, Fu W, Wei X, Ma G, Hu W, Lu C. Curcumin ameliorates IL‐1β‐induced apoptosis by activating autophagy and inhibiting the NF‐κB signaling pathway in rat primary articular chondrocytes. Cell Biology International 2021, 45: 976-988. PMID: 33377585, DOI: 10.1002/cbin.11541.Peer-Reviewed Original ResearchConceptsIL-1βChondrocyte apoptosisProtective effectNF-κBPrimary articular chondrocytesNF-κB inhibitor pyrrolidine dithiocarbamatePhosphorylation levelsArticular chondrocytesCurcumin-mediated protectionWnt/β-catenin inhibitorInhibitor pyrrolidine dithiocarbamateIL-1β stimulationArticular chondrocyte apoptosisArticular cartilage damageΒ-catenin inhibitorMechanism of curcuminArticular cartilage diseaseSynthase kinase-3βCurcumin pretreatmentRheumatoid arthritisΚB p65Chondrocyte injuryInterleukin-1βCartilage damageXAV-939
2017
ASIC1a Promotes Acid-Induced Autophagy in Rat Articular Chondrocytes through the AMPK/FoxO3a Pathway
Dai B, Zhu F, Chen Y, Zhou R, Wang Z, Xie Y, Wu X, Zu S, Li G, Ge J, Chen F. ASIC1a Promotes Acid-Induced Autophagy in Rat Articular Chondrocytes through the AMPK/FoxO3a Pathway. International Journal Of Molecular Sciences 2017, 18: 2125. PMID: 29019932, PMCID: PMC5666807, DOI: 10.3390/ijms18102125.Peer-Reviewed Original Research