2018
Role of eIF3a in 4-amino-2-trifluoromethyl-phenyl retinate-induced cell differentiation in human chronic myeloid leukemia K562 cells
Li G, Wang K, Li Y, Ruan J, Wang C, Qian Y, Zu S, Dai B, Meng Y, Zhou R, Ge J, Chen F. Role of eIF3a in 4-amino-2-trifluoromethyl-phenyl retinate-induced cell differentiation in human chronic myeloid leukemia K562 cells. Gene 2018, 683: 195-209. PMID: 30340049, DOI: 10.1016/j.gene.2018.10.035.Peer-Reviewed Original ResearchConceptsMyeloid differentiation marker CD11bCyclin D1Trans retinoic acid (ATRA) derivativeK562 cellsAnti-tumor effectsChronic myeloid leukemia K562 cellsMyeloid leukemia cell differentiationRetinoic acid derivativesCell differentiationG0/G1 phaseExpression of eIF3aC-MycHuman chronic myeloid leukemia K562 cellsDifferentiation marker CD11bTumor cell proliferationRole of eIF3aActivation of ERK1/2Marker CD11bCML cellsLeukemia cell differentiationP-ERKLeukemia K562 cellsPhenyl retinateP-RafEIF3a expressionAcute Ethanol Exposure Promotes Autophagy-Lysosome Pathway-Dependent ASIC1a Protein Degradation and Protects Against Acidosis-Induced Neurotoxicity
Zhou R, Leng T, Yang T, Chen F, Xiong Z. Acute Ethanol Exposure Promotes Autophagy-Lysosome Pathway-Dependent ASIC1a Protein Degradation and Protects Against Acidosis-Induced Neurotoxicity. Molecular Neurobiology 2018, 56: 3326-3340. PMID: 30120732, PMCID: PMC6378129, DOI: 10.1007/s12035-018-1289-0.Peer-Reviewed Original ResearchConceptsAcid-sensing ion channel 1aAutophagy-lysosome pathwayNeuronal cellsAcidosis-induced cytotoxicityAcute ethanol administrationAcute ethanol exposureActivity/expressionEthanol-induced reductionIon channel 1aAutophagy activator rapamycinAutophagy inhibitor CQEffects of ethanolASIC1a expressionIschemic strokeNeuronal injuryAcute treatmentBrain ischemiaNeuroprotective effectsEthanol administrationASIC currentsEthanol exposureTissue acidosisASIC1a channelsChannel 1aNeurotoxicity
2017
ASIC2a overexpression enhances the protective effect of PcTx1 and APETx2 against acidosis-induced articular chondrocyte apoptosis and cytotoxicity
Zhou R, Ni W, Dai B, Wu X, Wang Z, Xie Y, Wang Z, Yang W, Ge J, Hu W, Chen F. ASIC2a overexpression enhances the protective effect of PcTx1 and APETx2 against acidosis-induced articular chondrocyte apoptosis and cytotoxicity. Gene 2017, 642: 230-240. PMID: 29141196, DOI: 10.1016/j.gene.2017.11.034.Peer-Reviewed Original ResearchMeSH KeywordsAcid Sensing Ion Channel BlockersAcid Sensing Ion ChannelsAcidosisAlkanesulfonic AcidsAnimalsApoptosisCells, CulturedChondrocytesCnidarian VenomsCollagen Type IIDrug SynergismGene Expression RegulationGenetic VectorsMAP Kinase Signaling SystemMorpholinesPeptidesPlasmidsRatsSpider VenomsConceptsAcid-sensing ion channel 1aArticular chondrocyte apoptosisChondrocyte apoptosisChondrocyte cytotoxicityRheumatoid arthritisProtective effectExpression of ASIC1aAcidosis-induced injuryERK1/2 MAPK signaling pathwaysIon channel 1aAlone groupNeuroprotective effectsChondroprotective effectsMAPK signaling pathwaysProtective roleType II collagenChannel 1aNeuronal cellsAPETx2ASIC2aPcTx1Phosphorylated ERK1/2Pathological charactersInduced apoptosisII collagen