2024
TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis
Lin Y, Chen Y, Hu W, Liu X, Hao W, Xing J, Ding J, Xu Y, Yao F, Zhao Y, Wang K, Li S, Yu Q, Hu W, Zhou R. TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis. International Immunopharmacology 2024, 132: 111933. PMID: 38581988, DOI: 10.1016/j.intimp.2024.111933.Peer-Reviewed Original ResearchConceptsTransient receptor potential melastatin 7Rheumatoid arthritisInhibition of transient receptor potential melastatin 7Human RA patientsSynovial hyperplasiaAdjuvant-induced arthritis ratsIncreased TRPM7 expressionIL-6 mRNATreatment of RAPathogenesis of RAFibroblast-like synoviocytesTRPM7 silencingProgression of rheumatoid arthritisTRPM7 expressionChannel inhibitionCation channelsRA patientsMetastasisPharmacological inhibitionArthritis ratsInflammationNuclear translocationSynoviocyte proliferationHyperplasiaProliferation
2021
Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases
Liang H, Chen Y, Wei X, Ma G, Ding J, Lu C, Zhou R, Hu W. Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases. Immunology 2021, 165: 3-21. PMID: 34558663, DOI: 10.1111/imm.13420.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesAutoimmunityBiomarkersDisease SusceptibilityDrug DevelopmentGene Expression RegulationHumansImmune SystemImmunomodulationIon Channel GatingOrgan SpecificityProtein Kinase InhibitorsProtein Serine-Threonine KinasesSignal TransductionStructure-Activity RelationshipTRPM Cation ChannelsConceptsAutoimmune diseasesRole of TRPM7New treatment targetsPotential therapeutic targetReceptor ion channelsImmune toleranceRheumatoid arthritisMultiple sclerosisSystemic disordersBody of evidenceImmune cellsCytokine secretionImmunoreactive substancesFunctional damageImmunomodulatory functionsTherapeutic targetTreatment targetsDiseaseEffective interventionsPharmacological propertiesOne-tissueTRPM7Physiologic conditionsInappropriate responsesCell migration
2018
Necrostatin-1 ameliorates adjuvant arthritis rat articular chondrocyte injury via inhibiting ASIC1a-mediated necroptosis
Chen Y, Zhu C, Zhu F, Dai B, Song S, Wang Z, Feng Y, Ge J, Zhou R, Chen F. Necrostatin-1 ameliorates adjuvant arthritis rat articular chondrocyte injury via inhibiting ASIC1a-mediated necroptosis. Biochemical And Biophysical Research Communications 2018, 504: 843-850. PMID: 30219231, DOI: 10.1016/j.bbrc.2018.09.031.Peer-Reviewed Original ResearchConceptsRat articular cartilageRheumatoid arthritisNec-1Necrostatin-1Potential therapeutic strategyAcid-induced increaseChannel inhibitor amilorideArticular cartilage damageReceptor interacting protein 1Articular cartilageRIP1/RIP3Chondrocyte injuryAA ratsCartilage damageTherapeutic strategiesRA treatmentCartilage injuryPathophysiological processesPsalmotoxin-1Inhibitor necrostatin-1Expression of RIP1Inhibitor amilorideRIP1 inhibitor necrostatin-1Interacting protein 1ASIC1a