2024
Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases
Zhou R, Hu W, Ma P, Liu C. Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases. Bone Research 2024, 12: 58. PMID: 39406741, PMCID: PMC11480210, DOI: 10.1038/s41413-024-00370-4.Peer-Reviewed Original ResearchTRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis
Lin Y, Chen Y, Hu W, Liu X, Hao W, Xing J, Ding J, Xu Y, Yao F, Zhao Y, Wang K, Li S, Yu Q, Hu W, Zhou R. TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis. International Immunopharmacology 2024, 132: 111933. PMID: 38581988, DOI: 10.1016/j.intimp.2024.111933.Peer-Reviewed Original ResearchConceptsTransient receptor potential melastatin 7Rheumatoid arthritisInhibition of transient receptor potential melastatin 7Human RA patientsSynovial hyperplasiaAdjuvant-induced arthritis ratsIncreased TRPM7 expressionIL-6 mRNATreatment of RAPathogenesis of RAFibroblast-like synoviocytesTRPM7 silencingProgression of rheumatoid arthritisTRPM7 expressionChannel inhibitionCation channelsRA patientsMetastasisPharmacological inhibitionArthritis ratsInflammationNuclear translocationSynoviocyte proliferationHyperplasiaProliferation
2022
Transient receptor potential melastatin 7 and their modulators
Cheng X, Li S, Chen Y, Zhao Y, Hu W, Lu C, Zhou R. Transient receptor potential melastatin 7 and their modulators. European Journal Of Pharmacology 2022, 931: 175180. PMID: 35940237, DOI: 10.1016/j.ejphar.2022.175180.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationMammalsNeoplasmsProtein KinasesSignal TransductionTRPM Cation ChannelsConceptsUnique domain structureCation channelsRegulation of TRPM7Transient receptor potential melastatin 7Molecular signaling pathwaysProtein kinaseFunction of TRPM7Regulatory mechanismsPhysiological processesInternal regulatory mechanismsSignaling pathwaysExogenous regulationNonselective cation channelsCell membraneTRPM7Development of tumorsCell proliferationTRPM7 activityPhenotypic transformationRegulationPharmacological compoundsImportant targetIntracellular MgTRPM7 expressionTissue fibrosis
2021
Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases
Liang H, Chen Y, Wei X, Ma G, Ding J, Lu C, Zhou R, Hu W. Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases. Immunology 2021, 165: 3-21. PMID: 34558663, DOI: 10.1111/imm.13420.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesAutoimmunityBiomarkersDisease SusceptibilityDrug DevelopmentGene Expression RegulationHumansImmune SystemImmunomodulationIon Channel GatingOrgan SpecificityProtein Kinase InhibitorsProtein Serine-Threonine KinasesSignal TransductionStructure-Activity RelationshipTRPM Cation ChannelsConceptsAutoimmune diseasesRole of TRPM7New treatment targetsPotential therapeutic targetReceptor ion channelsImmune toleranceRheumatoid arthritisMultiple sclerosisSystemic disordersBody of evidenceImmune cellsCytokine secretionImmunoreactive substancesFunctional damageImmunomodulatory functionsTherapeutic targetTreatment targetsDiseaseEffective interventionsPharmacological propertiesOne-tissueTRPM7Physiologic conditionsInappropriate responsesCell migrationSystemic pharmacological investigation of the Feng Shi Gu Tong capsule in the treatment of rheumatoid arthritis
Wei X, Fu W, Zhou R, Chen Y, Lu C, Hu W. Systemic pharmacological investigation of the Feng Shi Gu Tong capsule in the treatment of rheumatoid arthritis. Naunyn-Schmiedeberg's Archives Of Pharmacology 2021, 394: 1285-1299. PMID: 33527195, DOI: 10.1007/s00210-021-02048-8.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisTreatment of RAActive rheumatoid arthritisDisease target networkChinese traditional patent medicineTraditional Chinese medicineRA diseaseMolecular mechanismsImmune responsePharmacological effectsPrecise molecular mechanismsClinical practiceSystemic pharmacologyPharmacological investigationsElimination parametersChinese medicinePatent medicinePotential mechanismsDirect targetArthritisTreatmentCandidate compoundsTotalCapsuleProtein-protein interaction networkCurcumin ameliorates IL‐1β‐induced apoptosis by activating autophagy and inhibiting the NF‐κB signaling pathway in rat primary articular chondrocytes
Chen T, Zhou R, Chen Y, Fu W, Wei X, Ma G, Hu W, Lu C. Curcumin ameliorates IL‐1β‐induced apoptosis by activating autophagy and inhibiting the NF‐κB signaling pathway in rat primary articular chondrocytes. Cell Biology International 2021, 45: 976-988. PMID: 33377585, DOI: 10.1002/cbin.11541.Peer-Reviewed Original ResearchConceptsIL-1βChondrocyte apoptosisProtective effectNF-κBPrimary articular chondrocytesNF-κB inhibitor pyrrolidine dithiocarbamatePhosphorylation levelsArticular chondrocytesCurcumin-mediated protectionWnt/β-catenin inhibitorInhibitor pyrrolidine dithiocarbamateIL-1β stimulationArticular chondrocyte apoptosisArticular cartilage damageΒ-catenin inhibitorMechanism of curcuminArticular cartilage diseaseSynthase kinase-3βCurcumin pretreatmentRheumatoid arthritisΚB p65Chondrocyte injuryInterleukin-1βCartilage damageXAV-939
2020
Novel insights into ferroptosis: Implications for age-related diseases
Zhou R, Chen Y, Wei X, Yu B, Xiong Z, Lu C, Hu W. Novel insights into ferroptosis: Implications for age-related diseases. Theranostics 2020, 10: 11976-11997. PMID: 33204324, PMCID: PMC7667696, DOI: 10.7150/thno.50663.Peer-Reviewed Original ResearchConceptsAge-related diseasesInhibition of ferroptosisNew treatment strategiesMolecular signaling pathwaysOrgan failureIron-dependent cell deathCardiovascular diseaseTreatment strategiesTherapeutic targetProgressive deteriorationEffective interventionsDiseaseOlder adultsHealthcare systemFerroptosisSignaling pathwaysCell deathNormal developmentIndirect involvementTissueUrgent needNovel insightsRegulatory mechanismsPathogenesis
2019
ROS play an important role in ATPR inducing differentiation and inhibiting proliferation of leukemia cells by regulating the PTEN/PI3K/AKT signaling pathway
Feng Y, Hua X, Niu R, Du Y, Shi C, Zhou R, Chen F. ROS play an important role in ATPR inducing differentiation and inhibiting proliferation of leukemia cells by regulating the PTEN/PI3K/AKT signaling pathway. Biological Research 2019, 52: 26. PMID: 31053167, PMCID: PMC6498685, DOI: 10.1186/s40659-019-0232-9.Peer-Reviewed Original ResearchConceptsPI3K/Akt pathwayPTEN/PI3K/AKT pathwayPTEN/PI3K/AKTPI3K/AktReactive oxygen speciesTrans retinoic acid (ATRA) derivativeAnti-AML effectAkt pathwayTreatment of AMLBackgroundAcute myeloid leukemiaCell proliferationAnti-tumor characteristicsIncurable hematological malignancyRetinoic acid derivativesG0/G1 phaseCCK-8 assayCell cycle distributionCell differentiationDifferentiation-related proteinFrequent relapsesStandard chemotherapyClinical outcomesCell line NB4Myeloid leukemiaNovel therapies
2017
Interleukin-1β and tumor necrosis factor-α augment acidosis-induced rat articular chondrocyte apoptosis via nuclear factor-kappaB-dependent upregulation of ASIC1a channel
Zhou R, Dai B, Xie Y, Wu X, Wang Z, Li Y, Wang Z, Zu S, Ge J, Chen F. Interleukin-1β and tumor necrosis factor-α augment acidosis-induced rat articular chondrocyte apoptosis via nuclear factor-kappaB-dependent upregulation of ASIC1a channel. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2017, 1864: 162-177. PMID: 28986307, DOI: 10.1016/j.bbadis.2017.10.004.Peer-Reviewed Original ResearchConceptsAcid-sensing ion channel 1aIL-1βRheumatoid arthritisInterleukin-1βNF-κB inhibitor ammonium pyrrolidinedithiocarbamateNF-κB DNA-binding activityPrimary articular chondrocytesProinflammatory cytokine interleukin-1βAcidosis-induced cytotoxicityCytokines interleukin-1βTumor necrosis factorImportant pathological characteristicNF-κB pathwayArticular chondrocyte apoptosisCaspase-3/9 expressionIon channel 1aNuclear factor-kappaBPleiotropic biological effectsArticular chondrocytesAgent BAPTA-AMASIC1a expressionChondrocyte cytotoxicityΚB expressionAdjuvant arthritisPathological characteristics