2024
Efferocytosis: Unveiling its potential in autoimmune disease and treatment strategies
Xing J, Wang K, Xu Y, Pei Z, Yu Q, Liu X, Dong Y, Li S, Chen Y, Zhao Y, Yao F, Ding J, Hu W, Zhou R. Efferocytosis: Unveiling its potential in autoimmune disease and treatment strategies. Autoimmunity Reviews 2024, 23: 103578. PMID: 39004157, DOI: 10.1016/j.autrev.2024.103578.Peer-Reviewed Original ResearchClearance of apoptotic cellsApoptotic cellsDegradation of apoptotic cellsPhagocyte surface receptorsAutoimmune diseasesInternalize apoptotic cellsEfficient clearance of apoptotic cellsSelf-antigensRelease of self-antigensSystemic lupus erythematosusTreat autoimmune diseasesSignaling pathwayType 1 diabetesSurface receptorsImmunosuppressive signalsImmune toleranceLupus erythematosusImmune homeostasisTreatment strategiesEfferocytosis processEfficient clearanceInadequate clearanceTherapeutic strategiesImmune responsePhagocytes
2020
Novel insights into ferroptosis: Implications for age-related diseases
Zhou R, Chen Y, Wei X, Yu B, Xiong Z, Lu C, Hu W. Novel insights into ferroptosis: Implications for age-related diseases. Theranostics 2020, 10: 11976-11997. PMID: 33204324, PMCID: PMC7667696, DOI: 10.7150/thno.50663.Peer-Reviewed Original ResearchConceptsAge-related diseasesInhibition of ferroptosisNew treatment strategiesMolecular signaling pathwaysOrgan failureIron-dependent cell deathCardiovascular diseaseTreatment strategiesTherapeutic targetProgressive deteriorationEffective interventionsDiseaseOlder adultsHealthcare systemFerroptosisSignaling pathwaysCell deathNormal developmentIndirect involvementTissueUrgent needNovel insightsRegulatory mechanismsPathogenesis