2024
Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases
Zhou R, Hu W, Ma P, Liu C. Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases. Bone Research 2024, 12: 58. PMID: 39406741, PMCID: PMC11480210, DOI: 10.1038/s41413-024-00370-4.Peer-Reviewed Original ResearchNav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis
Fu W, Vasylyev D, Bi Y, Zhang M, Sun G, Khleborodova A, Huang G, Zhao L, Zhou R, Li Y, Liu S, Cai X, He W, Cui M, Zhao X, Hettinghouse A, Good J, Kim E, Strauss E, Leucht P, Schwarzkopf R, Guo E, Samuels J, Hu W, Attur M, Waxman S, Liu C. Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis. Nature 2024, 625: 557-565. PMID: 38172636, PMCID: PMC10794151, DOI: 10.1038/s41586-023-06888-7.Peer-Reviewed Original ResearchVoltage-gated sodium channelsOA progressionDorsal root ganglion neuronsStructural joint damagePain relief treatmentHuman OA chondrocytesCommon joint diseaseMultiple mouse modelsNav1.7 blockersPain behaviorGanglion neuronsPharmacological blockadeJoint damageJoint degenerationChannel blockersJoint diseaseOA chondrocytesMouse modelTherapeutic targetOsteoarthritisIntracellular Ca2Nav1.7Nav1.7 channelsGenetic ablationLimited evidence
2023
Functions of Peroxiredoxins and Their Roles in Autoimmune Diseases
Zhou F, Chen F, Ouyang Z, Zhu R, Zhou R, Hu W, Lu C. Functions of Peroxiredoxins and Their Roles in Autoimmune Diseases. Antioxidants & Redox Signaling 2023, 40: 329-344. PMID: 36738225, DOI: 10.1089/ars.2022.0139.Peer-Reviewed Original ResearchFunction of peroxiredoxinsAutoimmune diseasesCellular redox signalingOxidative stressRedox signalingRedox homeostasisEssential regulatorExcess ROSPeroxiredoxinsBiological processesReactive oxygen species generationProduction of ROSPhysiological roleNew therapeutic targetsOxygen species generationAntioxidant enzymesPotential targetPathophysiological rolePathological situationsEffective treatmentTherapeutic targetSpecies generationDiseaseROSRecent studies
2022
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases
Zhou R, Liang H, Hu W, Ding J, Li S, Chen Y, Zhao Y, Lu C, Chen F, Hu W. Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases. Ageing Research Reviews 2022, 83: 101785. PMID: 36371015, DOI: 10.1016/j.arr.2022.101785.Peer-Reviewed Original ResearchConceptsAcid-sensing ion channel 1aAge-related diseasesTherapeutic targetPotential therapeutic targetMost age-related diseasesIon channel 1aNovel drug targetsEffective drugsMultiple organsPathophysiological processesChannel 1aDiseaseChannel family membersPharmacological propertiesImproved treatmentSuch diseasesTissue degenerationCellular apoptosisTreatmentDrug targetsFamily membersPhysiological functionsUrgent needWorldwide populationIschemiaRegulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis
Lin Y, Zhao Y, Zhang H, Hao W, Zhu R, Wang Y, Hu W, Zhou R. Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis. Frontiers In Immunology 2022, 13: 997621. PMID: 36275686, PMCID: PMC9580404, DOI: 10.3389/fimmu.2022.997621.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisSynovial inflammationImmune cellsCollagen antibody-induced arthritis modelAntibody-induced arthritis modelCartilage/bone destructionPathogenesis of RACommon autoimmune diseaseImmune cell functionPotential therapeutic targetIntermediate-conductance CaImmune balanceRA patientsBone destructionImmune dysfunctionChronic inflammationArthritis modelAutoimmune diseasesPeripheral bloodArticular synoviumPathological progressionCartilage damageKCa3.1 channelsTherapeutic targetAbnormal activation
2021
Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases
Liang H, Chen Y, Wei X, Ma G, Ding J, Lu C, Zhou R, Hu W. Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases. Immunology 2021, 165: 3-21. PMID: 34558663, DOI: 10.1111/imm.13420.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesAutoimmunityBiomarkersDisease SusceptibilityDrug DevelopmentGene Expression RegulationHumansImmune SystemImmunomodulationIon Channel GatingOrgan SpecificityProtein Kinase InhibitorsProtein Serine-Threonine KinasesSignal TransductionStructure-Activity RelationshipTRPM Cation ChannelsConceptsAutoimmune diseasesRole of TRPM7New treatment targetsPotential therapeutic targetReceptor ion channelsImmune toleranceRheumatoid arthritisMultiple sclerosisSystemic disordersBody of evidenceImmune cellsCytokine secretionImmunoreactive substancesFunctional damageImmunomodulatory functionsTherapeutic targetTreatment targetsDiseaseEffective interventionsPharmacological propertiesOne-tissueTRPM7Physiologic conditionsInappropriate responsesCell migration
2020
Novel insights into ferroptosis: Implications for age-related diseases
Zhou R, Chen Y, Wei X, Yu B, Xiong Z, Lu C, Hu W. Novel insights into ferroptosis: Implications for age-related diseases. Theranostics 2020, 10: 11976-11997. PMID: 33204324, PMCID: PMC7667696, DOI: 10.7150/thno.50663.Peer-Reviewed Original ResearchConceptsAge-related diseasesInhibition of ferroptosisNew treatment strategiesMolecular signaling pathwaysOrgan failureIron-dependent cell deathCardiovascular diseaseTreatment strategiesTherapeutic targetProgressive deteriorationEffective interventionsDiseaseOlder adultsHealthcare systemFerroptosisSignaling pathwaysCell deathNormal developmentIndirect involvementTissueUrgent needNovel insightsRegulatory mechanismsPathogenesis
2016
Functions of interleukin‐34 and its emerging association with rheumatoid arthritis
Zhou R, Wu X, Xie Y, Dai B, Hu W, Ge J, Chen F. Functions of interleukin‐34 and its emerging association with rheumatoid arthritis. Immunology 2016, 149: 362-373. PMID: 27550090, PMCID: PMC5095491, DOI: 10.1111/imm.12660.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisIL-34Inflammatory arthritisAutoimmune diseasesDevelopment of RAInterleukin-34Active rheumatoid arthritisSystemic autoimmune diseaseEffective treatment optionExtra-articular lesionsNovel therapeutic strategiesMononuclear phagocyte lineage cellsSynovial inflammationTreatment optionsSpecific monoclonal antibodiesTherapeutic strategiesTherapeutic targetArthritisMonoclonal antibodiesExperimental modelLineage cellsMultiple jointsReceptor ligandsInflammationDisease
2015
Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative Diseases.
Zhou R, Wu X, Wang Z, Xie Y, Ge J, Chen F. Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative Diseases. Aging And Disease 2015, 7: 491-501. PMID: 27493834, PMCID: PMC4963192, DOI: 10.14336/ad.2015.1213.Peer-Reviewed Original ResearchAcid-sensing ion channelsDegenerative diseasesActivation of ASICsEffective treatment optionIon channelsLigand-gated ion channelsIntervertebral disc degenerationMultiple sclerosisTreatment optionsParkinson's diseaseTherapeutic targetDegenerative disordersDisc degenerationProgressive deteriorationDiseaseAberrant activationHuntington's diseaseOlder adultsCritical roleCell apoptosisPathological conditionsOrgan degenerationDegenerationPotential utilityActivation