2024
TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis
Lin Y, Chen Y, Hu W, Liu X, Hao W, Xing J, Ding J, Xu Y, Yao F, Zhao Y, Wang K, Li S, Yu Q, Hu W, Zhou R. TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis. International Immunopharmacology 2024, 132: 111933. PMID: 38581988, DOI: 10.1016/j.intimp.2024.111933.Peer-Reviewed Original ResearchConceptsTransient receptor potential melastatin 7Rheumatoid arthritisInhibition of transient receptor potential melastatin 7Human RA patientsSynovial hyperplasiaAdjuvant-induced arthritis ratsIncreased TRPM7 expressionIL-6 mRNATreatment of RAPathogenesis of RAFibroblast-like synoviocytesTRPM7 silencingProgression of rheumatoid arthritisTRPM7 expressionChannel inhibitionCation channelsRA patientsMetastasisPharmacological inhibitionArthritis ratsInflammationNuclear translocationSynoviocyte proliferationHyperplasiaProliferation
2018
4-Amino-2-Trifluoromethyl-Phenyl Retinate induced leukemia cell differentiation by decreasing eIF6
Wang K, Wang C, Zhu C, Li G, Li Y, Feng Y, Ruan J, Zhu F, Meng Y, Zhou R, Chen F. 4-Amino-2-Trifluoromethyl-Phenyl Retinate induced leukemia cell differentiation by decreasing eIF6. Biochemical And Biophysical Research Communications 2018, 503: 2033-2039. PMID: 30078681, DOI: 10.1016/j.bbrc.2018.07.153.Peer-Reviewed Original ResearchConceptsLeukemia cell differentiationTrans retinoic acid (ATRA) derivativeEukaryotic translation initiation factor 6Cell proliferationEffects of ATPRRetinoic acid derivativesCell differentiationSurface antigen CD11bDifferentiation of K562Potential molecular mechanismsProliferation of K562Leukemia cell linesPhenyl retinateATPRInnovative treatmentsLeukemia cellsCell surface antigen CD11bCell linesC-MycFactor 6Induced differentiationK562ProliferationMolecular mechanismsCBF