2023
ASIC1a-CMPK2-mediated M1 macrophage polarization exacerbates chondrocyte senescence in osteoarthritis through IL-18
Dong L, Zhao Y, Sun C, Ou Yang Z, Chen F, Hu W, Zhang H, Wang Y, Zhu R, Cheng Y, Chen Y, Li S, Wang K, Ding C, Zhou R, Hu W. ASIC1a-CMPK2-mediated M1 macrophage polarization exacerbates chondrocyte senescence in osteoarthritis through IL-18. International Immunopharmacology 2023, 124: 110878. PMID: 37660594, DOI: 10.1016/j.intimp.2023.110878.Peer-Reviewed Original ResearchAcid-sensing ion channel 1aM1 macrophage polarizationM1 macrophagesChondrocyte senescenceMacrophage polarizationIL-18OA patientsPcTX-1IL-18 stimulationOA cartilage damageArticular cartilage destructionMouse OA modelIntra-articular administrationPromising treatment targetIon channel 1aMacrophage-associated genesMacrophage-mediated diseasesMechanism of actionASIC1a expressionOA miceCartilage destructionM1 polarizationCartilage damageOA modelSynovial fluid
2022
Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation
Ding J, Chen Y, Zhao Y, Chen F, Dong L, Zhang H, Hu W, Li S, Zhou R, Hu W. Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation. Biochemical Pharmacology 2022, 202: 115107. PMID: 35643339, DOI: 10.1016/j.bcp.2022.115107.Peer-Reviewed Original ResearchConceptsAcid-sensitive ion channel 1aChondrocyte senescenceIon channel 1aChannel 1aBeclin-1Chronic joint diseaseBeclin-1 protein expressionRat OA modelProtein Beclin 1Senescence-related markersJoint diseaseOA modelAging of chondrocytesJoint cavityPsalmotoxin-1Chondrocyte autophagyOsteoarthritisB1 expressionProtein expressionCationic channelsHairpin RNALamin B1Autophagy pathwayArticular cartilageLamin B1 expression