Role of eIF3a in 4-amino-2-trifluoromethyl-phenyl retinate-induced cell differentiation in human chronic myeloid leukemia K562 cells
Li G, Wang K, Li Y, Ruan J, Wang C, Qian Y, Zu S, Dai B, Meng Y, Zhou R, Ge J, Chen F. Role of eIF3a in 4-amino-2-trifluoromethyl-phenyl retinate-induced cell differentiation in human chronic myeloid leukemia K562 cells. Gene 2018, 683: 195-209. PMID: 30340049, DOI: 10.1016/j.gene.2018.10.035.Peer-Reviewed Original ResearchConceptsMyeloid differentiation marker CD11bCyclin D1Trans retinoic acid (ATRA) derivativeK562 cellsAnti-tumor effectsChronic myeloid leukemia K562 cellsMyeloid leukemia cell differentiationRetinoic acid derivativesCell differentiationG0/G1 phaseExpression of eIF3aC-MycHuman chronic myeloid leukemia K562 cellsDifferentiation marker CD11bTumor cell proliferationRole of eIF3aActivation of ERK1/2Marker CD11bCML cellsLeukemia cell differentiationP-ERKLeukemia K562 cellsPhenyl retinateP-RafEIF3a expression