2022
TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis
Zhou R, Chen Y, Li S, Wei X, Hu W, Tang S, Ding J, Fu W, Zhang H, Chen F, Hao W, Lin Y, Zhu R, Wang K, Dong L, Zhao Y, Feng X, Chen F, Ding C, Hu W. TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis. Redox Biology 2022, 55: 102411. PMID: 35917680, PMCID: PMC9344030, DOI: 10.1016/j.redox.2022.102411.Peer-Reviewed Original ResearchArticular cartilage destructionRheumatoid arthritisCartilage destructionChannel inhibitionPharmacological inhibitionTreatment of RAHuman RA patientsAdjuvant arthritis ratsExpression of TRPM7Primary rat articular chondrocytesArticular cartilage damageArticular chondrocytesRat articular chondrocytesRA patientsArthritis ratsTRPM7 channel activityAA ratsCartilage damageIntracellular CaVirus 9Human chondrocytesPromising targetFerroptosis inducersFerroptosisTRPM7
2019
β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation
Zhou R, Leng T, Yang T, Chen F, Hu W, Xiong Z. β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation. Stroke 2019, 50: 2902-2911. PMID: 31412757, PMCID: PMC6756944, DOI: 10.1161/strokeaha.119.025940.Peer-Reviewed Original ResearchConceptsIschemic neuronal injuryIschemic brain injuryΒ-estradiol treatmentASIC1a protein expressionNeuronal injuryASIC currentsBrain injuryProtein expressionΒ-estradiolWhole-cell patch-clamp techniqueIntracellular CaAcidosis-induced cytotoxicityAcidosis-mediated injuryActivation of ASIC1aDegree of neuroprotectionOutcome of strokeSeverity of strokeMiddle cerebral arteryTransient focal ischemiaOnline visual overviewAcid-induced elevationEstrogen receptor αReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionPatch-clamp technique