2024
Efferocytosis: Unveiling its potential in autoimmune disease and treatment strategies
Xing J, Wang K, Xu Y, Pei Z, Yu Q, Liu X, Dong Y, Li S, Chen Y, Zhao Y, Yao F, Ding J, Hu W, Zhou R. Efferocytosis: Unveiling its potential in autoimmune disease and treatment strategies. Autoimmunity Reviews 2024, 23: 103578. PMID: 39004157, DOI: 10.1016/j.autrev.2024.103578.Peer-Reviewed Original ResearchClearance of apoptotic cellsApoptotic cellsDegradation of apoptotic cellsPhagocyte surface receptorsAutoimmune diseasesInternalize apoptotic cellsEfficient clearance of apoptotic cellsSelf-antigensRelease of self-antigensSystemic lupus erythematosusTreat autoimmune diseasesSignaling pathwayType 1 diabetesSurface receptorsImmunosuppressive signalsImmune toleranceLupus erythematosusImmune homeostasisTreatment strategiesEfferocytosis processEfficient clearanceInadequate clearanceTherapeutic strategiesImmune responsePhagocytes
2021
Systemic pharmacological investigation of the Feng Shi Gu Tong capsule in the treatment of rheumatoid arthritis
Wei X, Fu W, Zhou R, Chen Y, Lu C, Hu W. Systemic pharmacological investigation of the Feng Shi Gu Tong capsule in the treatment of rheumatoid arthritis. Naunyn-Schmiedeberg's Archives Of Pharmacology 2021, 394: 1285-1299. PMID: 33527195, DOI: 10.1007/s00210-021-02048-8.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisTreatment of RAActive rheumatoid arthritisDisease target networkChinese traditional patent medicineTraditional Chinese medicineRA diseaseMolecular mechanismsImmune responsePharmacological effectsPrecise molecular mechanismsClinical practiceSystemic pharmacologyPharmacological investigationsElimination parametersChinese medicinePatent medicinePotential mechanismsDirect targetArthritisTreatmentCandidate compoundsTotalCapsuleProtein-protein interaction network