2024
TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis
Lin Y, Chen Y, Hu W, Liu X, Hao W, Xing J, Ding J, Xu Y, Yao F, Zhao Y, Wang K, Li S, Yu Q, Hu W, Zhou R. TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis. International Immunopharmacology 2024, 132: 111933. PMID: 38581988, DOI: 10.1016/j.intimp.2024.111933.Peer-Reviewed Original ResearchConceptsTransient receptor potential melastatin 7Rheumatoid arthritisInhibition of transient receptor potential melastatin 7Human RA patientsSynovial hyperplasiaAdjuvant-induced arthritis ratsIncreased TRPM7 expressionIL-6 mRNATreatment of RAPathogenesis of RAFibroblast-like synoviocytesTRPM7 silencingProgression of rheumatoid arthritisTRPM7 expressionChannel inhibitionCation channelsRA patientsMetastasisPharmacological inhibitionArthritis ratsInflammationNuclear translocationSynoviocyte proliferationHyperplasiaProliferation
2022
TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis
Zhou R, Chen Y, Li S, Wei X, Hu W, Tang S, Ding J, Fu W, Zhang H, Chen F, Hao W, Lin Y, Zhu R, Wang K, Dong L, Zhao Y, Feng X, Chen F, Ding C, Hu W. TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis. Redox Biology 2022, 55: 102411. PMID: 35917680, PMCID: PMC9344030, DOI: 10.1016/j.redox.2022.102411.Peer-Reviewed Original ResearchArticular cartilage destructionRheumatoid arthritisCartilage destructionChannel inhibitionPharmacological inhibitionTreatment of RAHuman RA patientsAdjuvant arthritis ratsExpression of TRPM7Primary rat articular chondrocytesArticular cartilage damageArticular chondrocytesRat articular chondrocytesRA patientsArthritis ratsTRPM7 channel activityAA ratsCartilage damageIntracellular CaVirus 9Human chondrocytesPromising targetFerroptosis inducersFerroptosisTRPM7