2022
Transient receptor potential melastatin 7 and their modulators
Cheng X, Li S, Chen Y, Zhao Y, Hu W, Lu C, Zhou R. Transient receptor potential melastatin 7 and their modulators. European Journal Of Pharmacology 2022, 931: 175180. PMID: 35940237, DOI: 10.1016/j.ejphar.2022.175180.Peer-Reviewed Original ResearchConceptsUnique domain structureCation channelsRegulation of TRPM7Transient receptor potential melastatin 7Molecular signaling pathwaysProtein kinaseFunction of TRPM7Regulatory mechanismsPhysiological processesInternal regulatory mechanismsSignaling pathwaysExogenous regulationNonselective cation channelsCell membraneTRPM7Development of tumorsCell proliferationTRPM7 activityPhenotypic transformationRegulationPharmacological compoundsImportant targetIntracellular MgTRPM7 expressionTissue fibrosis
2019
ROS play an important role in ATPR inducing differentiation and inhibiting proliferation of leukemia cells by regulating the PTEN/PI3K/AKT signaling pathway
Feng Y, Hua X, Niu R, Du Y, Shi C, Zhou R, Chen F. ROS play an important role in ATPR inducing differentiation and inhibiting proliferation of leukemia cells by regulating the PTEN/PI3K/AKT signaling pathway. Biological Research 2019, 52: 26. PMID: 31053167, PMCID: PMC6498685, DOI: 10.1186/s40659-019-0232-9.Peer-Reviewed Original ResearchConceptsPI3K/Akt pathwayPTEN/PI3K/AKT pathwayPTEN/PI3K/AKTPI3K/AktReactive oxygen speciesTrans retinoic acid (ATRA) derivativeAnti-AML effectAkt pathwayTreatment of AMLBackgroundAcute myeloid leukemiaCell proliferationAnti-tumor characteristicsIncurable hematological malignancyRetinoic acid derivativesG0/G1 phaseCCK-8 assayCell cycle distributionCell differentiationDifferentiation-related proteinFrequent relapsesStandard chemotherapyClinical outcomesCell line NB4Myeloid leukemiaNovel therapies
2018
4-Amino-2-Trifluoromethyl-Phenyl Retinate induced leukemia cell differentiation by decreasing eIF6
Wang K, Wang C, Zhu C, Li G, Li Y, Feng Y, Ruan J, Zhu F, Meng Y, Zhou R, Chen F. 4-Amino-2-Trifluoromethyl-Phenyl Retinate induced leukemia cell differentiation by decreasing eIF6. Biochemical And Biophysical Research Communications 2018, 503: 2033-2039. PMID: 30078681, DOI: 10.1016/j.bbrc.2018.07.153.Peer-Reviewed Original ResearchConceptsLeukemia cell differentiationTrans retinoic acid (ATRA) derivativeEukaryotic translation initiation factor 6Cell proliferationEffects of ATPRRetinoic acid derivativesCell differentiationSurface antigen CD11bDifferentiation of K562Potential molecular mechanismsProliferation of K562Leukemia cell linesPhenyl retinateATPRInnovative treatmentsLeukemia cellsCell surface antigen CD11bCell linesC-MycFactor 6Induced differentiationK562ProliferationMolecular mechanismsCBF