2024
TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis
Lin Y, Chen Y, Hu W, Liu X, Hao W, Xing J, Ding J, Xu Y, Yao F, Zhao Y, Wang K, Li S, Yu Q, Hu W, Zhou R. TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis. International Immunopharmacology 2024, 132: 111933. PMID: 38581988, DOI: 10.1016/j.intimp.2024.111933.Peer-Reviewed Original ResearchConceptsTransient receptor potential melastatin 7Rheumatoid arthritisInhibition of transient receptor potential melastatin 7Human RA patientsSynovial hyperplasiaAdjuvant-induced arthritis ratsIncreased TRPM7 expressionIL-6 mRNATreatment of RAPathogenesis of RAFibroblast-like synoviocytesTRPM7 silencingProgression of rheumatoid arthritisTRPM7 expressionChannel inhibitionCation channelsRA patientsMetastasisPharmacological inhibitionArthritis ratsInflammationNuclear translocationSynoviocyte proliferationHyperplasiaProliferation
2022
Transient receptor potential melastatin 7 and their modulators
Cheng X, Li S, Chen Y, Zhao Y, Hu W, Lu C, Zhou R. Transient receptor potential melastatin 7 and their modulators. European Journal Of Pharmacology 2022, 931: 175180. PMID: 35940237, DOI: 10.1016/j.ejphar.2022.175180.Peer-Reviewed Original ResearchConceptsUnique domain structureCation channelsRegulation of TRPM7Transient receptor potential melastatin 7Molecular signaling pathwaysProtein kinaseFunction of TRPM7Regulatory mechanismsPhysiological processesInternal regulatory mechanismsSignaling pathwaysExogenous regulationNonselective cation channelsCell membraneTRPM7Development of tumorsCell proliferationTRPM7 activityPhenotypic transformationRegulationPharmacological compoundsImportant targetIntracellular MgTRPM7 expressionTissue fibrosis