2021
Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway
Ma G, Yang Y, Chen Y, Wei X, Ding J, Zhou R, Hu W. Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway. Frontiers In Pharmacology 2021, 12: 655551. PMID: 33927631, PMCID: PMC8076952, DOI: 10.3389/fphar.2021.655551.Peer-Reviewed Original ResearchArticular cartilage damageAdjuvant arthritisChondrocyte apoptosisCartilage damageIL-6Rat modelMMP-13Adjuvant arthritis rat modelRat adjuvant arthritisArthritis rat modelMajor pathological featureADAMTS-5 expressionBcl-2/Bax ratioIndian hedgehogArticular cartilage injuryTransient receptor potential melastatinBcl-2/Arthritis scoreRheumatoid arthritisPathological featuresChondrocyte injuryAA ratsADAMTS-5Articular diseaseClinical signs
2019
Effects of autophagy on apoptosis of articular chondrocytes in adjuvant arthritis rats
Zhou R, Zhu F, Wu X, Song S, Chen Y, Zhu C, Dai B, Qian X, Wang K, Hu W, Chen F. Effects of autophagy on apoptosis of articular chondrocytes in adjuvant arthritis rats. Journal Of Cellular And Molecular Medicine 2019, 23: 7879-7884. PMID: 31508906, PMCID: PMC6815768, DOI: 10.1111/jcmm.14629.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisEffect of autophagyChondrocyte apoptosisAdjuvant arthritisDevelopment of RATreatment of RASystemic autoimmune diseaseAdjuvant arthritis ratsArticular chondrocyte apoptosisAutophagy activator rapamycinArticular cartilage injuryArticular chondrocytesRat articular cartilageArthritis ratsJoint deformityAutoimmune diseasesAA ratsCartilage injuryJoint functionChondrocyte autophagyAutophagy inhibitorPotential targetArthritisApoptosisRats