2014
Low-copper diet as a preventive strategy for Alzheimer's disease
Squitti R, Siotto M, Polimanti R. Low-copper diet as a preventive strategy for Alzheimer's disease. Neurobiology Of Aging 2014, 35: s40-s50. PMID: 24913894, DOI: 10.1016/j.neurobiolaging.2014.02.031.Peer-Reviewed Original ResearchConceptsLow copper dietAlzheimer's diseasePreventive strategiesRisk of ADSporadic Alzheimer's diseaseCopper metabolismAdverse sequelaeDietary intakePathogenetic mechanismsGeneral populationAD riskPathogenic mechanismsDiseaseDietCopper deficiencyRecent studiesRiskMetabolismPhenotypeSequelaeDerangementIntake
2013
ATP7B Variants as Modulators of Copper Dyshomeostasis in Alzheimer’s Disease
Squitti R, Polimanti R, Siotto M, Bucossi S, Ventriglia M, Mariani S, Vernieri F, Scrascia F, Trotta L, Rossini PM. ATP7B Variants as Modulators of Copper Dyshomeostasis in Alzheimer’s Disease. NeuroMolecular Medicine 2013, 15: 515-522. PMID: 23760784, DOI: 10.1007/s12017-013-8237-y.Peer-Reviewed Original ResearchMetal-score as a potential non-invasive diagnostic test for Alzheimer's disease.
Squitti R, Pasqualetti P, Polimanti R, Salustri C, Moffa F, Cassetta E, Lupoi D, Ventriglia M, Cortesi M, Siotto M, Vernieri F, Rossini PM. Metal-score as a potential non-invasive diagnostic test for Alzheimer's disease. Current Alzheimer Research 2013, 10: 191-8. PMID: 23036026, DOI: 10.2174/1567205011310020009.Peer-Reviewed Original Research
2012
Copper Hypothesis in the Missing Hereditability of Sporadic Alzheimer's Disease: ATP7B Gene as Potential Harbor of Rare Variants
Squitti R, Polimanti R. Copper Hypothesis in the Missing Hereditability of Sporadic Alzheimer's Disease: ATP7B Gene as Potential Harbor of Rare Variants. Journal Of Alzheimer's Disease 2012, 29: 493-501. PMID: 22258517, DOI: 10.3233/jad-2011-111991.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesRare variantsMultiple rare variantsRare gene variantsATP7B geneGene variantsAssociation studiesHigh heritabilityGenesPotential harbourGenetic contributionCopper imbalanceSporadic Alzheimer's diseaseGenetic risk factorsHeritabilityCopper involvementPivotal roleCopper toxicosisAllele variantsRecent studiesAlzheimer's diseaseParadigmatic diseaseVariantsWilson's diseaseHereditability