Lack of Association Between Essential Hypertension and GSTO1 Uncommon Genetic Variants in Italian Patients
Polimanti R, Piacentini S, Lazzarin N, Re MA, Manfellotto D, Fuciarelli M. Lack of Association Between Essential Hypertension and GSTO1 Uncommon Genetic Variants in Italian Patients. Genetic Testing And Molecular Biomarkers 2012, 16: 615-620. PMID: 22283150, DOI: 10.1089/gtmb.2011.0310.Peer-Reviewed Original ResearchConceptsEssential hypertensionLack of associationEH patientsUncommon variantEH riskUncommon genetic variantsGlutathione S-transferaseGenetic variantsMale patientsHealthy controlsItalian patientsPatientsCommon polymorphismsStatistical significance levelSignificant outcomesFunctional effectsHypertensionPotential roleHaplotype investigationGenetic association analysisLack of association between GSTM1, GSTP1, and GSTT1 gene polymorphisms and asthma in adult patients from Rome, central Italy.
Piacentini S, Polimanti R, Moscatelli B, Re MA, Manfellotto D, Fuciarelli M. Lack of association between GSTM1, GSTP1, and GSTT1 gene polymorphisms and asthma in adult patients from Rome, central Italy. Journal Of Investigational Allergology And Clinical Immunology 2012, 22: 252-6. PMID: 22812193.Peer-Reviewed Original ResearchConceptsDevelopment of asthmaAsthma developmentPolymerase chain reactionGSTP1 polymorphismsGlutathione S-transferaseGene polymorphismsOxidative stressGST gene polymorphismsLack of associationGSTT1 gene polymorphismsComplex multifactorial diseasePCR-restriction fragment length polymorphism analysisAsthmatic patientsAdult patientsAsthma pathogenesisInflammatory responseAsthma riskGST polymorphismsAsthmaMultiplex polymerase chain reactionHealthy individualsAntioxidant defense systemGSTT1 genesMultifactorial diseaseUnrelated healthy individuals