2012
Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women
Polimanti R, Piacentini S, Lazzarin N, Vaquero E, Re MA, Manfellotto D, Fuciarelli M. Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women. Fertility And Sterility 2012, 98: 396-400. PMID: 22633257, DOI: 10.1016/j.fertnstert.2012.05.003.Peer-Reviewed Original ResearchConceptsRecurrent miscarriageT alleleRisk of RMGSTA1 geneGlutathione S-transferaseGSTM1 variantsPregnancy complicationsRM riskMAIN OUTCOMEGST polymorphismsRM groupNull genotypeControl groupGSTT1 genesSignificant associationGSTP1 geneBuccal cellsItalian womenDifferent genetic modelsSingle nucleotide polymorphismsWomenGSTA1MiscarriageRiskGenetic association studiesLack of association between GSTM1, GSTP1, and GSTT1 gene polymorphisms and asthma in adult patients from Rome, central Italy.
Piacentini S, Polimanti R, Moscatelli B, Re MA, Manfellotto D, Fuciarelli M. Lack of association between GSTM1, GSTP1, and GSTT1 gene polymorphisms and asthma in adult patients from Rome, central Italy. Journal Of Investigational Allergology And Clinical Immunology 2012, 22: 252-6. PMID: 22812193.Peer-Reviewed Original ResearchConceptsDevelopment of asthmaAsthma developmentPolymerase chain reactionGSTP1 polymorphismsGlutathione S-transferaseGene polymorphismsOxidative stressGST gene polymorphismsLack of associationGSTT1 gene polymorphismsComplex multifactorial diseasePCR-restriction fragment length polymorphism analysisAsthmatic patientsAdult patientsAsthma pathogenesisInflammatory responseAsthma riskGST polymorphismsAsthmaMultiplex polymerase chain reactionHealthy individualsAntioxidant defense systemGSTT1 genesMultifactorial diseaseUnrelated healthy individuals
2011
Glutathione S-transferase variants as risk factor for essential hypertension in Italian patients
Polimanti R, Piacentini S, Lazzarin N, Re MA, Manfellotto D, Fuciarelli M. Glutathione S-transferase variants as risk factor for essential hypertension in Italian patients. Molecular And Cellular Biochemistry 2011, 357: 227-233. PMID: 21656129, DOI: 10.1007/s11010-011-0893-3.Peer-Reviewed Original ResearchConceptsEssential hypertensionArterial hypertensionGST null polymorphismsRisk of hypertensionBlood pressure regulationGSTT1 null individualsGST gene polymorphismsGlutathione S-transferase variantsSex-based analysisHypertensive patientsHypertensive subjectsNormotensive participantsFemale hypertensivesHealthy controlsRisk factorsPCR-RFLP methodHypertensionGST polymorphismsItalian patientsOral swabsGene polymorphismsNull polymorphismGSTO polymorphismsMale subjectsPossible association