Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics
Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC. Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Cell Reports 2017, 20: 1978-1990. PMID: 28834758, PMCID: PMC5573767, DOI: 10.1016/j.celrep.2017.08.003.Peer-Reviewed Original ResearchConceptsHuman immune responseHumanized miceImmune cellsImmune responseStem cell allograftsInnate immune cellsAllogeneic stem cellsStem cellsMouse immune systemAlloimmune responseCell allograftsImmunodeficient miceMouse modelGraft persistenceImmune systemHuman lymphocytesMiceAllograftsStem cell therapeuticsCell therapeuticsPluripotent stem cellsEmbryonic stem cellsCellsAlloimmunityResponse