Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo
Kooreman NG, Kim Y, de Almeida PE, Termglinchan V, Diecke S, Shao NY, Wei TT, Yi H, Dey D, Nelakanti R, Brouwer TP, Paik DT, Sagiv-Barfi I, Han A, Quax PHA, Hamming JF, Levy R, Davis MM, Wu JC. Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo. Cell Stem Cell 2018, 22: 501-513.e7. PMID: 29456158, PMCID: PMC6134179, DOI: 10.1016/j.stem.2018.01.016.Peer-Reviewed Original ResearchConceptsElicit anti-tumor responsesAnti-tumor responseInduced pluripotent stem cellsTumor growthMetastatic tumor loadTumor-associated antigensAnti-tumor vaccinesMurine breast cancerTumor-bearing miceAutologous induced pluripotent stem cellsUnvaccinated recipientsProphylactic settingAdoptive transferClinical immunotherapyCancer vaccinesTumor loadMelanoma recurrenceBreast cancerResection siteMelanoma modelMyeloid cellsCell responsesVaccineCancer cellsCancer