2023
Therapeutics for Substance-Using Women: The Need to Elucidate Sex-Specific Targets for Better-Tailored Treatments
Fox H, Milivojevic V, Sinha R. Therapeutics for Substance-Using Women: The Need to Elucidate Sex-Specific Targets for Better-Tailored Treatments. Handbook Of Experimental Pharmacology 2023, 282: 127-161. PMID: 37592081, DOI: 10.1007/164_2023_687.Peer-Reviewed Original ResearchConceptsSubstance-using womenExogenous progesteroneBetter tailor treatmentsStress-induced cravingFace of stressSex-specific targetsGender-related differencesAdrenergic medicationsStress-related adaptationClinical trialsSpecific treatmentMedication developmentAlcohol consumptionCompulsive drugBiobehavioral mechanismsDrinking historyMedical problemsInnovative medicationsMedicationsNovel targetWomenGuanfacineProgesteroneTreatmentEfficacyMifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study
Haass‐Koffler C, Magill M, Cannella N, Brown J, Aoun E, Cioe P, Sinha R, Swift R, Ciccocioppo R, Leggio L. Mifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study. Addiction Biology 2023, 28: e13288. PMID: 37369125, PMCID: PMC10313137, DOI: 10.1111/adb.13288.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHuman laboratory studiesAdverse eventsAlcohol pharmacokineticsAlcohol cravingSubjective effectsSafety of mifepristonePlacebo-controlled trialStress-induced alcoholLack of effectCue-reactivity procedureBlood pressurePhase 1/2Alcohol drinkingGeneralized Estimating EquationsYohimbine administrationHemodynamic parametersPharmacological interventionsSaliva outputDay administrationUse disordersMifepristoneNon-treatment seekersAlcohol consumptionPlacebo conditionHypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology
Syed S, Sinha R, Milivojevic V, MacDougall A, LaValle H, Angarita G, Fox H. Hypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology. Human Psychopharmacology Clinical And Experimental 2023, 38: e2867. PMID: 37165544, DOI: 10.1002/hup.2867.Peer-Reviewed Original ResearchConceptsAlcohol use disorderRelapse riskDepressive symptomatologyDepressive symptomsAutonomic responsesIndividual relapse riskChronic alcohol useDepressive pathophysiologyAdrenocorticotropic hormoneInhibitory systemPlasma measuresUse disordersClinical practicePhasic changesConsecutive daysAlcohol usePsychological stressStroop performanceDisorder individualsDrinking controlsSymptomatologyImagery exposureCounterbalanced orderSymptomsDepression
2022
Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder
Milivojevic V, Sullivan L, Tiber J, Fogelman N, Simpson C, Hermes G, Sinha R. Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder. Psychopharmacology 2022, 240: 101-114. PMID: 36445398, PMCID: PMC10630889, DOI: 10.1007/s00213-022-06278-3.Peer-Reviewed Original ResearchConceptsAlcohol use disorderDiastolic blood pressureHeart rateGABAergic transmissionNeuroactive steroidsHPA axisRelapse riskUse disordersAlcohol cravingTreatment of AUDAlcohol cue-induced cravingPilot clinical trialStress-induced anxietyCue-induced cravingAutonomic arousalNeurosteroid systemPreg groupStudy drugDBP responseBlood pressureDay groupClinical trialsPregnenolone levelsWeek 2Cue-provoked craving
1994
Effects of ethanol on the acoustic startle reflex in humans
Grillon C, Sinha R, O'Malley S. Effects of ethanol on the acoustic startle reflex in humans. Psychopharmacology 1994, 114: 167-171. PMID: 7846199, DOI: 10.1007/bf02245459.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdultBlinkingElectromyographyEthanolFemaleHumansMaleReflex, StartleConceptsEffects of ethanolStartle responsePrepulse inhibitionPrepulse stimulusStartle reflexHealthy normal subjectsAcoustic startle reflexAcoustic startle responseAcute ethanolSensorimotor reactivityNormal subjectsStartle amplitudeStartle reactivitySeparate daysReflex experimentsReflexStartle probesInhibitionStimuliPlaceboResponse
1993
Simple Reaction Time Event‐Related Potentials: Effects of Alcohol and Sleep Deprivation
Krull K, Smith L, Sinha R, Parsons O. Simple Reaction Time Event‐Related Potentials: Effects of Alcohol and Sleep Deprivation. Alcohol Clinical And Experimental Research 1993, 17: 771-777. PMID: 8214412, DOI: 10.1111/j.1530-0277.1993.tb00839.x.Peer-Reviewed Original ResearchConceptsBreath alcohol concentrationSleep deprivationNormal male subjectsEvent-related potentialsLatency of N2Effects of alcoholVisual event-related potentialsMale subjectsAlcohol intoxicationSimple reaction timeResponse activationStimulus detectionDeprivationAlcohol concentrationNegative componentTreatmentAdditive increase
1990
Relationships between Neuropsychological Test Performance and Event‐Related Potentials in Alcoholic and Nonalcoholic Samples
Parsons O, Sinha R, Williams H. Relationships between Neuropsychological Test Performance and Event‐Related Potentials in Alcoholic and Nonalcoholic Samples. Alcohol Clinical And Experimental Research 1990, 14: 746-755. PMID: 2264605, DOI: 10.1111/j.1530-0277.1990.tb01239.x.Peer-Reviewed Original ResearchConceptsEvent-related potentialsNeuropsychological test performanceTest performanceEvent-related potential taskPerceptual-motor testsFamily history positive alcoholicsERP differencesMiddle-aged alcoholicsERP measuresERP responsesP3 amplitudeNeuropsychological testsP3 latencyERP variablesPM testNP measuresPeer controlsNP performanceFemale alcoholicsSober alcoholicsNonalcoholic samplesMale alcoholicsPotential tasksMental disordersNP test