2023
Mifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study
Haass‐Koffler C, Magill M, Cannella N, Brown J, Aoun E, Cioe P, Sinha R, Swift R, Ciccocioppo R, Leggio L. Mifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study. Addiction Biology 2023, 28: e13288. PMID: 37369125, PMCID: PMC10313137, DOI: 10.1111/adb.13288.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHuman laboratory studiesAdverse eventsAlcohol pharmacokineticsAlcohol cravingSubjective effectsSafety of mifepristonePlacebo-controlled trialStress-induced alcoholLack of effectCue-reactivity procedureBlood pressurePhase 1/2Alcohol drinkingGeneralized Estimating EquationsYohimbine administrationHemodynamic parametersPharmacological interventionsSaliva outputDay administrationUse disordersMifepristoneNon-treatment seekersAlcohol consumptionPlacebo condition
2005
Chapter 3.7 Stress and drug abuse
Sinha R. Chapter 3.7 Stress and drug abuse. Techniques In The Behavioral And Neural Sciences 2005, 15: 333-356. DOI: 10.1016/s0921-0709(05)80063-x.Peer-Reviewed Original ResearchRole of stressAddictive processDrug abuseMost major theoriesDrug-seeking behaviorStress-related copingFuture researchModels of addictionHuman laboratory studiesField of addictionSubstantial preclinical dataChronic drug abuseDrug useTreatment developmentMajor theoriesCurrent knowledge baseStress exposureAbuseLittle direct evidenceAddictionEmpirical evidencePreclinical dataCopingEpidemiological studiesClinical observations
2001
How does stress increase risk of drug abuse and relapse?
Sinha R. How does stress increase risk of drug abuse and relapse? Psychopharmacology 2001, 158: 343-359. PMID: 11797055, DOI: 10.1007/s002130100917.Peer-Reviewed Original ResearchConceptsDrug abuseSubstance abuseMost major theoriesHuman laboratory studiesField of addictionDrug seekingDrug useTreatment developmentMajor theoriesAbuse altersStress exposureVulnerable individualsHuman researchAbuseAddictsEmpirical evidencePreclinical evidenceClinical observationsRelapseAnimal studiesPreclinical researchSeekingGreater understandingAddictionResearch