2022
Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Milivojevic V, Charron L, Fogelman N, Hermes G, Sinha R. Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder. Biomolecules 2022, 12: 1593. PMID: 36358943, PMCID: PMC9687893, DOI: 10.3390/biom12111593.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureCocaine use disorderHeart ratePrecursor pregnenoloneUse disordersCocaine cravingCue-induced cocaine cravingCue-induced anxietyWeeks of treatmentCue-induced cravingAutonomic arousalChronic cocaine usePreg groupBlood pressureDay groupRelapse riskHigher cocainePregnenolone levelsCue-provoked cravingSeparate daysAutonomic responsesCocaine useTreatment-seeking individualsCravingSteroid systems
2017
Chapter 69 Patient Responses to Guanfacine in Cocaine Addiction
Milivojevic V, Sinha R, Fox H. Chapter 69 Patient Responses to Guanfacine in Cocaine Addiction. 2017, 679-688. DOI: 10.1016/b978-0-12-803750-8.00069-5.ChaptersAnxiety pathophysiologyDrugs of abuseNeural stress systemsDrug-seeking behaviorEmotional controlDrug seekingRecent research findingsChronic stress stateNegative consequencesCocaine addictionCocaine dependenceStress systemResearch findingsLong-term agentsCocaine useDrug useAbuseGuanfacineCravingSeekingStress sensitivityAddictionAbilityRobust adaptationOwn laboratory
2010
Cocaine
Beech R, Sinha R. Cocaine. 2010, 397-416. DOI: 10.1007/978-1-4419-0338-9_18.Peer-Reviewed Original ResearchCognitive behavior therapyBehavior therapyCocaine dependenceGeneral cognitive behavior therapyContingency managementRelapse prevention techniquesCompulsive drug seekingReward-related informationContingency management techniquesCocaine-taking behaviorConditions of challengeExecutive controlLong-term neuroadaptationsCocaine-related disordersDrug seekingCocaine useAdditional clinical attentionExtended abstinenceAnxiety disordersNeurobiological aspectsChronic cocaine useRegular cocaine useRelapse preventionPsychological symptomsNegative consequences
2006
Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes
Sinha R, Garcia M, Paliwal P, Kreek MJ, Rounsaville BJ. Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes. JAMA Psychiatry 2006, 63: 324-331. PMID: 16520439, DOI: 10.1001/archpsyc.63.3.324.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultBehavior, AddictiveCocaine-Related DisordersCuesFemaleFollow-Up StudiesHospitalizationHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemProspective StudiesSecondary PreventionStress, PsychologicalSubstance Abuse Treatment CentersTreatment OutcomeConceptsAdrenal axis responseCocaine cravingRelapse outcomesAxis responseCocaine relapseAdrenal responseInpatient treatmentCocaine relapse outcomesCue-induced cocaine cravingStress-induced drug cravingCocaine useCocaine dependenceCox proportional hazards regressionCommunity mental health centerProportional hazards regressionMental health centersProspective study designDrug cue exposureStress-related increasesTreatment-seeking cocaine dependent individualsHazards regressionHypothalamic-PituitaryHealth centersCocaine-dependent individualsRelapse
2000
Prevalence of family violence in clients entering substance abuse treatment
Easton C, Swan S, Sinha R. Prevalence of family violence in clients entering substance abuse treatment. Journal Of Substance Use And Addiction Treatment 2000, 18: 23-28. PMID: 10636603, DOI: 10.1016/s0740-5472(99)00019-7.Peer-Reviewed Original ResearchConceptsSubstance-using clientsIndividual therapy sessionsChildhood traumaFamily violenceAdult victimsTherapy sessionsPhysical violenceHigher scoresSubstance abuse treatmentSubstance-related problemsMichigan Alcoholism Screening TestPositive urine screenChildhood abuseAbuse treatmentChildhood victimsSubstance abusersDepression Inventory scoresAlcoholism Screening TestBeck Depression Inventory scoresFamily historyInventory scoresCocaine useVictimsDomestic violencePerpetrators