2024
Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice
Islam R, White J, Arefin T, Mehta S, Liu X, Polis B, Giuliano L, Ahmed S, Bowers C, Zhang J, Kaffman A. Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice. Biology Of Sex Differences 2024, 15: 39. PMID: 38715106, PMCID: PMC11075329, DOI: 10.1186/s13293-024-00616-0.Peer-Reviewed Original ResearchConceptsLateral entorhinal cortexContextual fear conditioningDorsal hippocampusHippocampal developmentSex differencesFear conditioningEarly adversityLimited beddingSevere deficitsModel of early adversitySex-specific deficitsReelin-positive neuronsPerforant pathwayReelin-positive cellsDiffusion magnetic resonance imagingEx vivo diffusion magnetic resonance imagingContextual freezingContextual memoryAdolescent miceHippocampal functionLife adversityEntorhinal cortexHippocampusDeficitsAdolescent males
2021
Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway
Al Mamun A, Matsuzaki K, Islam R, Hossain S, Hossain ME, Katakura M, Arai H, Shido O, Hashimoto M. Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway. Neurochemical Research 2021, 47: 933-951. PMID: 34855048, DOI: 10.1007/s11064-021-03495-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoquinonesBrain-Derived Neurotrophic FactorHippocampusNeurogenesisRatsSignal TransductionConceptsBrain-derived neurotrophic factorChronic administrationCAMP response element-binding proteinAdult ratsHippocampal neurogenesisCREB/brain-derived neurotrophic factorBDNF Signaling PathwayChronic oral administrationAdult hippocampal neurogenesisNumber of bromodeoxyuridineEffect of TQCultured neural stem/progenitor cellsMature neuronal markersNeural stem/progenitor cellsNigella sativa LinnStem/progenitor cellsProfound beneficial effectsRats ViaWestern blot analysisBDNF pathwayProportion of cellsTQ treatmentAdult neurogenesisNeurotrophic factorDentate gyrusAnredera cordifolia extract enhances learning and memory in senescence-accelerated mouse-prone 8 (SAMP8) mice
Sumiyoshi E, Hashimoto M, Hossain S, Matsuzaki K, Islam R, Tanabe Y, Maruyama K, Kajima K, Arai H, Ohizumi Y, Shido O. Anredera cordifolia extract enhances learning and memory in senescence-accelerated mouse-prone 8 (SAMP8) mice. Food & Function 2021, 12: 3992-4004. PMID: 33977955, DOI: 10.1039/d0fo03272g.Peer-Reviewed Original ResearchConceptsBrain-derived neurotropic factorPlasticity-related proteinsBlood biochemistry parametersMemory deficitsSynaptic plasticity-related proteinsBiochemistry parametersNovel object recognition taskMorris water maze taskAC extractNoticeable side effectsWater maze taskNegative control groupAge-related memory deficitsAge-related declineHippocampal levelsNeurotropic factorOral administrationCognition declinePathological changesMouse modelSide effectsBehavioral testingNOR taskControl groupMemory impairment