Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration.
Guillén-Samander A, De Camilli P. Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration. Cold Spring Harbor Perspectives In Biology 2022, 15: a041257. PMID: 36123033, PMCID: PMC10071438, DOI: 10.1101/cshperspect.a041257.Peer-Reviewed Original ResearchConceptsMembrane contact sitesEndoplasmic reticulumEndoplasmic reticulum membrane contact sitesContact sitesLipid transportER membrane contact sitesCross talkLipid transfer proteinMutations of genesFamilial neurodegenerative diseasesIntracellular membranous organellesEndomembrane systemLipid trafficVesicular transportCell physiologyPlasma membraneMembranous organellesMembrane lipidsLipid exchangeTransfer proteinCell compartmentProteinNeurodegenerative diseasesMultiplicity of rolesDendritic tipsNovel pathways of intracellular membrane lipid transport and neurodegenerative diseases
De Camilli P. Novel pathways of intracellular membrane lipid transport and neurodegenerative diseases. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.0i152.ChaptersFamily proteinsLipid transportMembrane lipid transportMembrane contact sitesLipid binding modulesLipid transport proteinsLipid trafficRod-like proteinsBinding modulesHydrophobic grooveTransport proteinsContact sitesMembrane lipidsFunction mutationsLipid transferNovel pathwayNeurodevelopmental diseasesProteinVesicular carriersFamily resultsNeurodegenerative diseasesChorea-AcanthocytosisPotential roleNew mechanismMembrane