Medroxyprogesterone acetate and dihydrotestosterone induce coronary hyperreactivity in intact male rhesus monkeys.
Mishra RG, Hermsmeyer RK, Miyagawa K, Sarrel P, Uchida B, Stanczyk FZ, Burry KA, Illingworth DR, Nordt FJ. Medroxyprogesterone acetate and dihydrotestosterone induce coronary hyperreactivity in intact male rhesus monkeys. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 3706-14. PMID: 15769993, PMCID: PMC1473190, DOI: 10.1210/jc.2004-1557.Peer-Reviewed Original ResearchConceptsIntact male rhesus monkeysTP receptor expressionCoronary hyperreactivityVascular muscle cellsReceptor expressionMale rhesus monkeysAndrogen receptorEpicardial coronariesP receptorRhesus monkeysMuscle cellsAR antagonist flutamideProstanoid receptor expressionMedroxyprogesterone acetate treatmentAdult male primatesBrief vasoconstrictionDHT inductionIntracoronary serotoninVasoconstrictor challengesCoronary arteryMedroxyprogesterone acetateSevere vasoconstrictionAnalogue U46619Myocardial ischemiaDihydrotestosterone exposure