2021
Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis
Wang Z, Joshi A, Leopold K, Jackson S, Christensen S, Nayfeh T, Mohammed K, Creo A, Tebben P, Kumar S. Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis. Clinical Endocrinology 2021, 96: 281-287. PMID: 34160843, PMCID: PMC8444883, DOI: 10.1111/cen.14540.Peer-Reviewed Original ResearchConceptsVitamin D deficiencyD deficiencyCOVID-19 infectionAssociation of vitamin D deficiencyAssociated with significantly higher mortalityIntensive care unit admissionVitamin D supplementationHospital admissionSeverity of COVID-19 infectionSeverity of coronavirus disease 2019Length of hospitalizationSignificantly higher mortalityAssociated with greater severityCOVID-19 infection severitySeverity of COVID-19D supplementationStudy geographic locationUnit admissionRate of hospital admissionsLonger hospitalSubgroup analysisObservational studyCoronavirus disease 2019Higher mortalityMeta-analysis
2016
Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment
Tebben P, Singh R, Kumar R. Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment. Endocrine Reviews 2016, 37: 521-547. PMID: 27588937, PMCID: PMC5045493, DOI: 10.1210/er.2016-1070.Peer-Reviewed Original ResearchConceptsVitamin D receptorD receptorVitamin D-mediated hypercalcemiaElevated serum calcium concentrationsAssociated with elevated serumProduction of 1,25-dihydroxyvitamin DSuppressing PTH concentrationsAssociated with malignancyReduced bone densityRenal stone formersSerum calcium concentrationVitamin D metabolitesVitamin D<sub>3</sub>Primary hyperparathyroidismElevated serumPTH concentrationsMonoallelic mutationsClinical featuresCYP24A1 geneD metabolitesGranulomatous diseaseBiochemical diagnosisTumor cellsVitamin DHypercalcemiaClinical and biochemical phenotypes of adults with monoallelic and biallelic CYP24A1 mutations: evidence of gene dose effect
O’Keeffe D, Tebben P, Kumar R, Singh R, Wu Y, Wermers R. Clinical and biochemical phenotypes of adults with monoallelic and biallelic CYP24A1 mutations: evidence of gene dose effect. Osteoporosis International 2016, 27: 3121-3125. PMID: 27129455, DOI: 10.1007/s00198-016-3615-6.Peer-Reviewed Original ResearchConceptsMonoallelic mutationsGene dose effectCYP24A1 mutationsCYP24A1 geneBiallelic mutationsBiochemical phenotypeDisease manifestationsElevated serum 1,25(OH)2DBone turnover markersMutations of CYP24A1Dose effectCompound heterozygous mutationsVitamin D metabolitesLow PTH concentrationsSerum 1,25(OH)2DUrine calciumResultsThe probandTurnover markersUrinary calciumHeterozygous mutationsPTH concentrationsD metabolitesSequence informationIntroductionThe objectiveMedical history
2012
Vitamin D and the kidney
Kumar R, Tebben P, Thompson J. Vitamin D and the kidney. Archives Of Biochemistry And Biophysics 2012, 523: 77-86. PMID: 22426203, PMCID: PMC3361542, DOI: 10.1016/j.abb.2012.03.003.Peer-Reviewed Original Research