2024
Update on Practical Management of Early-Stage Non-Small Cell Lung Cancer (NSCLC): A Report from the Ontario Forum
Cheema P, Wheatley-Price P, Cecchini M, Ellis P, Louie A, Moore S, Sheffield B, Spicer J, Villeneuve P, Leighl N. Update on Practical Management of Early-Stage Non-Small Cell Lung Cancer (NSCLC): A Report from the Ontario Forum. Current Oncology 2024, 31: 6979-6999. DOI: 10.3390/curroncol31110514.Peer-Reviewed Original ResearchNon-small cell lung cancerEarly-stage non-small cell lung cancerImmune checkpoint inhibitorsCell lung cancerLung cancerManagement of early-stage non-small cell lung cancerPre-meeting surveyTreatment approachesReview practice patternsAdjuvant settingCheckpoint inhibitorsRadiation therapyOntario cancer centersTargeted therapySurgical considerationsTreatment algorithmReview recent dataClinical dataBiomarker testingCancer CenterTherapeutic strategiesPractice patternsCancerTherapyPatientsGrowth differentiation factor 15 (GDF15) predicts relapse free and overall survival in unresected locally advanced non-small cell lung cancer treated with chemoradiotherapy
Di Pastena F, Pond G, Tsakiridis E, Gouveia A, Ahmadi E, Biziotis O, Ali A, Swaminath A, Okawara G, Ellis P, Abdulkarim B, Ahmed N, Robinson A, Roa W, Valdes M, Kavsak P, Wierzbicki M, Wright J, Steinberg G, Tsakiridis T. Growth differentiation factor 15 (GDF15) predicts relapse free and overall survival in unresected locally advanced non-small cell lung cancer treated with chemoradiotherapy. Radiation Oncology 2024, 19: 155. PMID: 39511611, PMCID: PMC11542377, DOI: 10.1186/s13014-024-02546-y.Peer-Reviewed Original ResearchConceptsLocally advanced non-small cell lung cancerAdvanced non-small cell lung cancerNon-small cell lung cancerCell lung cancerOverall survivalDifferentiation factor 15GDF15 levelsLA-NSCLCTumor volumeSurvival outcomesUnresectable locally advanced non-small cell lung cancerLung cancerPhase II randomized clinical trialConcurrent chest radiotherapyIncreased GDF15 levelsUnresectable LA-NSCLCTreated with chemoradiotherapyGross target volumeGrowth differentiation factor 15Platinum-based chemotherapyPlasma GDF15 levelsRandomized to treatmentLevels of GDF15Patient blood plasmaRandomized clinical trialsCardiovascular Considerations During Cancer Therapy Gaps in Evidence and JACC: CardioOncology Expert Panel Recommendations
Leong D, Waliany S, Abdel-Qadir H, Atkins K, Neilan T, Lang N, Liu J, Blaes A, Mian H, Moore H, Hajjar L, Morgans A, Ellis P, Dent S. Cardiovascular Considerations During Cancer Therapy Gaps in Evidence and JACC: CardioOncology Expert Panel Recommendations. JACC CardioOncology 2024 DOI: 10.1016/j.jaccao.2024.06.005.Peer-Reviewed Original ResearchCardiovascular toxicityCancer therapyContinuation of cancer therapySpectrum of toxicityDiverse health care professionalsExpert panelSevere cardiovascular diseaseHealth care professionalsExpert panel recommendationsCardiovascular considerationsCardio-oncologyInvasive managementTherapy gapAdvanced cancerPrimary preventionTherapyCancerCardiovascular diseaseCardiovascular treatmentCare professionalsCardiovascular carePanel recommendationsPatientsToxicityTreatmentImplementation of Liquid Biopsy in Non-Small-Cell Lung Cancer: An Ontario Perspective
Breadner D, Hwang D, Husereau D, Cheema P, Doucette S, Ellis P, Kassam S, Leighl N, Maziak D, Selvarajah S, Sheffield B, Juergens R. Implementation of Liquid Biopsy in Non-Small-Cell Lung Cancer: An Ontario Perspective. Current Oncology 2024, 31: 6017-6031. PMID: 39451753, PMCID: PMC11505603, DOI: 10.3390/curroncol31100449.Peer-Reviewed Original ResearchNon-small-cell lung cancerAdvanced non-small-cell lung cancerCirculating tumor DNALung cancerMolecular profilingLiquid biopsyImplementation of liquid biopsiesComprehensive molecular profilingNon-small-cellHigh-risk patientsCancer-related deathsMinimally invasive methodTissue biopsy samplesTumor DNAInsufficient tissueMultidisciplinary working groupTherapy selectionTissue biopsiesBiomarker testingBiopsy samplesBiopsyGold standardInvasive methodEligibility criteriaCancerBiopsychosocial Associates of Psychological Distress and Post-Traumatic Growth among Canadian Cancer Patients during the COVID-19 Pandemic
Zhang K, Mukherjee S, Pond G, Roque M, Meyer R, Sussman J, Ellis P, Bryant-Lukosius D. Biopsychosocial Associates of Psychological Distress and Post-Traumatic Growth among Canadian Cancer Patients during the COVID-19 Pandemic. Current Oncology 2024, 31: 5354-5366. PMID: 39330023, PMCID: PMC11431811, DOI: 10.3390/curroncol31090395.Peer-Reviewed Original ResearchConceptsPost-traumatic growthCanadian cancer patientsPsychological distressAssociation of psychological distressAssociated with psychological distressLevels of psychological distressModerate to severe levelsPsychological patient outcomesFear of recurrenceAssociated with levels of distressCancer patientsSevere psychological distressCross-sectional surveyLevels of distressDisease-related informationRegional Cancer CentrePatient health recordsSelf-report questionnairesCOVID-19 pandemicSafety behaviorCancer careIllness perceptionsHealth recordsNegative psychological outcomesOngoing care
2023
Molecular Testing in Non–Small-Cell Lung Cancer: A Call to Action
Sathiyapalan A, Ellis P. Molecular Testing in Non–Small-Cell Lung Cancer: A Call to Action. JCO Oncology Practice 2023, 20: 7-9. PMID: 38033274, DOI: 10.1200/op.23.00669.Peer-Reviewed Original ResearchUpdate on the Management of Stage III NSCLC: Navigating a Complex and Heterogeneous Stage of Disease
Sathiyapalan A, Baloush Z, Ellis P. Update on the Management of Stage III NSCLC: Navigating a Complex and Heterogeneous Stage of Disease. Current Oncology 2023, 30: 9514-9529. PMID: 37999109, PMCID: PMC10670056, DOI: 10.3390/curroncol30110689.Peer-Reviewed Original ResearchConceptsStage III nonsmall cell lung cancerNonsmall cell lung cancerCurative-intent therapyDisease-free survivalEvent-free survivalPathologic complete responseStandard of careOverall survivalSystemic therapyUnresectable stage III nonsmall cell lung cancerResectable nonsmall cell lung cancerImmune checkpoint inhibitor therapyAddition of durvalumabPalliative systemic therapyBest supportive careCheckpoint inhibitor therapyNeoadjuvant systemic therapyManagement of patientsCell lung cancerConsolidation durvalumabPerioperative therapyConcurrent chemoradiationMultimodality therapySupportive careSurgical resection
2021
The mutational landscape of human somatic and germline cells
Moore L, Cagan A, Coorens T, Neville M, Sanghvi R, Sanders M, Oliver T, Leongamornlert D, Ellis P, Noorani A, Mitchell T, Butler T, Hooks Y, Warren A, Jorgensen M, Dawson K, Menzies A, O’Neill L, Latimer C, Teng M, van Boxtel R, Iacobuzio-Donahue C, Martincorena I, Heer R, Campbell P, Fitzgerald R, Stratton M, Rahbari R. The mutational landscape of human somatic and germline cells. Nature 2021, 597: 381-386. PMID: 34433962, DOI: 10.1038/s41586-021-03822-7.Peer-Reviewed Original ResearchConceptsCell typesMutational landscapeRate of mutationLow rate of cell divisionRate of cell divisionBasal spermatogoniaGermline cellsGenetic variationCell divisionHuman cellsMutational signaturesGermlineAcquired mutationsMutationsSpermatogoniaHuman populationCellsIndividual's lifetimeSBS5/40SpermSBS18Stem cellsSBS1LandscapeType
2000
Residents’ medical information needs in clinic: are they being met?
Green M, Ciampi M, Ellis P. Residents’ medical information needs in clinic: are they being met? The American Journal Of Medicine 2000, 109: 218-223. PMID: 10974185, DOI: 10.1016/s0002-9343(00)00458-7.Peer-Reviewed Original ResearchConceptsClinical questionsPatient encountersUnanswered clinical questionsEvidence-based medicineNew clinical questionsInternal medicine programsMultivariable analysisOutpatient clinicMedical informationFrequent reasonTeaching clinicClinic sessionsLack of timeLevel of agreementClinicCommon typeMalpractice exposureMedicine programsPatientsMissed opportunityOriginal articlesSeries of statementsResidentsTherapyPhysicians
1997
Impact of an Evidence‐Based Medicine Curriculum Based on Adult Learning Theory
Green M, Ellis P. Impact of an Evidence‐Based Medicine Curriculum Based on Adult Learning Theory. Journal Of General Internal Medicine 1997, 12: 742-750. PMID: 9436893, PMCID: PMC1497200, DOI: 10.1046/j.1525-1497.1997.07159.x.Peer-Reviewed Original ResearchConceptsEBM behaviourEvidence-Based Medicine CurriculumControl subjectsThird-year internal medicine residentsPrimary care internal medicine residency programEBM skillsInternal medicine residency programsReal clinical encountersResidents' EBM skillsMedicine curriculumInternal medicine residentsMedicine residency programsEvidence-based medicine skillsSelf-assessed competencyEBM curriculumClinical questionsEBM competenceOwn patientsFree-text responsesEvidence-based decisionsMultifaceted evaluationClinical encountersMedicine residentsEBM trainingMedicine skills