2024
Growth differentiation factor 15 (GDF15) predicts relapse free and overall survival in unresected locally advanced non-small cell lung cancer treated with chemoradiotherapy
Di Pastena F, Pond G, Tsakiridis E, Gouveia A, Ahmadi E, Biziotis O, Ali A, Swaminath A, Okawara G, Ellis P, Abdulkarim B, Ahmed N, Robinson A, Roa W, Valdes M, Kavsak P, Wierzbicki M, Wright J, Steinberg G, Tsakiridis T. Growth differentiation factor 15 (GDF15) predicts relapse free and overall survival in unresected locally advanced non-small cell lung cancer treated with chemoradiotherapy. Radiation Oncology 2024, 19: 155. PMID: 39511611, PMCID: PMC11542377, DOI: 10.1186/s13014-024-02546-y.Peer-Reviewed Original ResearchConceptsLocally advanced non-small cell lung cancerAdvanced non-small cell lung cancerNon-small cell lung cancerCell lung cancerOverall survivalDifferentiation factor 15GDF15 levelsLA-NSCLCTumor volumeSurvival outcomesUnresectable locally advanced non-small cell lung cancerLung cancerPhase II randomized clinical trialConcurrent chest radiotherapyIncreased GDF15 levelsUnresectable LA-NSCLCTreated with chemoradiotherapyGross target volumeGrowth differentiation factor 15Platinum-based chemotherapyPlasma GDF15 levelsRandomized to treatmentLevels of GDF15Patient blood plasmaRandomized clinical trialsBiopsychosocial Associates of Psychological Distress and Post-Traumatic Growth among Canadian Cancer Patients during the COVID-19 Pandemic
Zhang K, Mukherjee S, Pond G, Roque M, Meyer R, Sussman J, Ellis P, Bryant-Lukosius D. Biopsychosocial Associates of Psychological Distress and Post-Traumatic Growth among Canadian Cancer Patients during the COVID-19 Pandemic. Current Oncology 2024, 31: 5354-5366. PMID: 39330023, PMCID: PMC11431811, DOI: 10.3390/curroncol31090395.Peer-Reviewed Original ResearchConceptsPost-traumatic growthCanadian cancer patientsPsychological distressAssociation of psychological distressAssociated with psychological distressLevels of psychological distressModerate to severe levelsPsychological patient outcomesFear of recurrenceAssociated with levels of distressCancer patientsSevere psychological distressCross-sectional surveyLevels of distressDisease-related informationRegional Cancer CentrePatient health recordsSelf-report questionnairesCOVID-19 pandemicSafety behaviorCancer careIllness perceptionsHealth recordsNegative psychological outcomesOngoing care
2021
The mutational landscape of human somatic and germline cells
Moore L, Cagan A, Coorens T, Neville M, Sanghvi R, Sanders M, Oliver T, Leongamornlert D, Ellis P, Noorani A, Mitchell T, Butler T, Hooks Y, Warren A, Jorgensen M, Dawson K, Menzies A, O’Neill L, Latimer C, Teng M, van Boxtel R, Iacobuzio-Donahue C, Martincorena I, Heer R, Campbell P, Fitzgerald R, Stratton M, Rahbari R. The mutational landscape of human somatic and germline cells. Nature 2021, 597: 381-386. PMID: 34433962, DOI: 10.1038/s41586-021-03822-7.Peer-Reviewed Original ResearchConceptsCell typesMutational landscapeRate of mutationLow rate of cell divisionRate of cell divisionBasal spermatogoniaGermline cellsGenetic variationCell divisionHuman cellsMutational signaturesGermlineAcquired mutationsMutationsSpermatogoniaHuman populationCellsIndividual's lifetimeSBS5/40SpermSBS18Stem cellsSBS1LandscapeType