2017
Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system
Zhu Y, Zhang R, Zhang B, Zhao T, Wang P, Liang G, Cheng G. Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system. Nature Communications 2017, 8: 1262. PMID: 29093445, PMCID: PMC5665997, DOI: 10.1038/s41467-017-01244-6.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsArbovirusesBloodBunyamwera virusCulexDengue VirusEncephalitis Virus, CaliforniaEncephalitis Virus, JapaneseGABA-A Receptor AntagonistsGamma-Aminobutyric AcidHumansImmunity, InnateMosquito VectorsReceptors, GABA-ARNA, Double-StrandedSemliki forest virusSignal TransductionSindbis VirusVirus ReplicationConceptsGABAergic systemArboviral infectionsArbovirus replicationInfection of mosquitoesAntiviral innate immunityIngestion of bloodBlood protein digestionBlood mealGABA signalingBlood meal acquisitionGABAergic pathwayGABAA receptorsInnate immunityOral introductionGlutamic acidHematophagous insectsInfectionHuman virusesVirus acquisitionSpecific inhibitorGABAProtein digestionCommon mechanismHematophagous natureActivation
2016
Mosquito C-type lectins maintain gut microbiome homeostasis.
Pang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology 2016, 1: 16023. PMID: 27572642, DOI: 10.1038/nmicrobiol.2016.23.Peer-Reviewed Original ResearchConceptsC-type lectinMammalian host immune systemHost immune systemAntimicrobial peptidesMajor mosquito vectorsCommensal bacteriaEvolutionary interactionsMultiple bacterial strainsSymbiotic bacteriaGut microbiomeGut microbial floraGut microbiome homeostasisFacilitate colonizationImmune systemGut commensal bacteriaMicrobial floraBacterial surfaceMicrobiome homeostasisAntagonistic relationshipBacterial strainsHomeostasisA. aegyptiMicrobiomeHost immune responseMosquito vectors
2010
A C-Type Lectin Collaborates with a CD45 Phosphatase Homolog to Facilitate West Nile Virus Infection of Mosquitoes
Cheng G, Cox J, Wang P, Krishnan MN, Dai J, Qian F, Anderson JF, Fikrig E. A C-Type Lectin Collaborates with a CD45 Phosphatase Homolog to Facilitate West Nile Virus Infection of Mosquitoes. Cell 2010, 142: 714-725. PMID: 20797779, PMCID: PMC2954371, DOI: 10.1016/j.cell.2010.07.038.Peer-Reviewed Original ResearchConceptsWest Nile virusWNV infectionWest Nile virus infectionArthropod-borne flavivirusBlood-feeding processVirus infectionHuman CD45Viral disseminationC-type lectinInfectionViral entryViral attachmentMosquito homologCalcium-dependent mannerNile virusMolecular understandingVivo experimentsSame pathwayNatural vector