Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling
Ma J, Ketkar H, Geng T, Lo E, Wang L, Xi J, Sun Q, Zhu Z, Cui Y, Yang L, Wang P. Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling. Frontiers In Microbiology 2018, 9: 1350. PMID: 29988497, PMCID: PMC6026624, DOI: 10.3389/fmicb.2018.01350.Peer-Reviewed Original ResearchMelanoma differentiation-associated protein 5Zika virusImmune responseNon-structural protein 4AReceptor-mediated immune responsesToll-like receptor-mediated immune responsesRe-emerging flavivirusGuillain-Barre syndromeAntiviral immune responseType I interferon inductionHost immune systemI interferon inductionMammalian host immune systemProtein 4AN-terminal caspase activationMolecular mechanismsNeonatal microcephalyZIKV pathogenesisZIKV replicationImmune evasionImmune systemHuman trophoblastsReceptor signalingSubsequent inductionProtein 5