2024
A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes
Zhang L, Wang D, Shi P, Li J, Niu J, Chen J, Wang G, Wu L, Chen L, Yang Z, Li S, Meng J, Ruan F, He Y, Zhao H, Ren Z, Wang Y, Liu Y, Shi X, Wang Y, Liu Q, Li J, Wang P, Wang J, Zhu Y, Cheng G. A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes. Science 2024, 384: eadn9524. PMID: 38669573, DOI: 10.1126/science.adn9524.Peer-Reviewed Original ResearchConceptsColony forming unitsFlavivirus envelope proteinCommensal microbiotaIrreversible conformational changesGlucose dehydrogenaseMosquito gutConformational changesGut lumenPrevent viral infectionGutBacteriumFlavivirus transmissionEnvelope proteinsVector competencePrevent viral entryViral entryRefractory to infectionDengue virusForming unitsField mosquitoesTransmission of dengue virusFlavivirusesMosquitoesSemifield conditionsAdult mosquitoes
2022
A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness
Zhang H, Zhu Y, Liu Z, Peng Y, Peng W, Tong L, Wang J, Liu Q, Wang P, Cheng G. A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness. Cell 2022, 185: 2510-2522.e16. PMID: 35777355, DOI: 10.1016/j.cell.2022.05.016.Peer-Reviewed Original ResearchSkin microbiotaMosquito-transmitted flavivirusDengue patientsFlavivirus infectionFlavivirus life cycleDietary administrationHealthy peopleCommensal bacteriaZika virusHost skinMosquito attractivenessArboviral transmissionRELMαAedes mosquitoesMicrobiotaMosquito olfactionInfected hostAntimicrobial proteinsHematophagous arthropodsHost-seeking activityMosquitoesIsotretinoinPatientsInfectionMice
2021
A human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoes
Zhu Y, Zhang C, Zhang L, Yang Y, Yu X, Wang J, Liu Q, Wang P, Cheng G. A human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoes. Cell Reports 2021, 37: 110091. PMID: 34910910, DOI: 10.1016/j.celrep.2021.110091.Peer-Reviewed Original ResearchA mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host
Yu X, Shan C, Zhu Y, Ma E, Wang J, Wang P, Shi P, Cheng G. A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2113015118. PMID: 34620704, PMCID: PMC8545446, DOI: 10.1073/pnas.2113015118.Peer-Reviewed Original ResearchConceptsEvolutionary adaptationZIKV capsid proteinAsian ZIKV lineageZika virusMammalian hostsZIKV mutantsNS2B-NS3 proteaseStructural proteinsPreferred substrateHuman cellsCapsid proteinInfectious viral particlesMutantsMosquito vectorsZIKV disseminationMillions of infectionsZIKV lineagesProteinViral particlesHigh prevalenceImmunodeficient miceMosquito infectionExplosive outbreaksMosquitoesStable substitutionsGlucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH
Wang M, An Y, Gao L, Dong S, Zhou X, Feng Y, Wang P, Dimopoulos G, Tang H, Wang J. Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH. Cell Reports 2021, 35: 108992. PMID: 33882310, PMCID: PMC8116483, DOI: 10.1016/j.celrep.2021.108992.Peer-Reviewed Original ResearchConceptsPlasmodium infectionGlucose metabolismMalaria parasitesCommensal bacteriumMosquito midgutPlasmodium berghei infectionGut commensal bacteriumBerghei infectionMosquito-microbiota interactionsDietary glucoseInfectionMetabolome changesVector competencePlasmodium gametogenesisVector competencyGlucoseImportant determinantPlasmodiumProliferationMetabolismMosquitoesParasitesAsaia bogorensis
2020
A mosquito salivary protein promotes flavivirus transmission by activation of autophagy
Sun P, Nie K, Zhu Y, Liu Y, Wu P, Liu Z, Du S, Fan H, Chen CH, Zhang R, Wang P, Cheng G. A mosquito salivary protein promotes flavivirus transmission by activation of autophagy. Nature Communications 2020, 11: 260. PMID: 31937766, PMCID: PMC6959235, DOI: 10.1038/s41467-019-14115-z.Peer-Reviewed Original ResearchConceptsBeclin-1Viral transmissionFlavivirus transmissionMosquito salivary proteinsHost immune cellsZika virus transmissionActivation of autophagyLow viremiaProphylactic targetsMosquito salivaImmune cellsZIKV transmissionAllergen 1Infected mosquitoesViral infectionMonocyte lineageVirus transmissionMiceMosquitoesSalivary proteinsNumerous studiesViremiaInfectionFlavivirusesProtein
2019
Progress towards Understanding the Mosquito-Borne Virus Life Cycle
Yu X, Zhu Y, Xiao X, Wang P, Cheng G. Progress towards Understanding the Mosquito-Borne Virus Life Cycle. Trends In Parasitology 2019, 35: 1009-1017. PMID: 31669148, DOI: 10.1016/j.pt.2019.09.006.Peer-Reviewed Original ResearchAedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments
Du S, Liu Y, Liu J, Zhao J, Champagne C, Tong L, Zhang R, Zhang F, Qin CF, Ma P, Chen CH, Liang G, Liu Q, Shi PY, Cazelles B, Wang P, Tian H, Cheng G. Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments. Nature Communications 2019, 10: 1324. PMID: 30902991, PMCID: PMC6430813, DOI: 10.1038/s41467-019-09256-0.Peer-Reviewed Original ResearchArbovirus lifecycle in mosquito: acquisition, propagation and transmission
Wu P, Yu X, Wang P, Cheng G. Arbovirus lifecycle in mosquito: acquisition, propagation and transmission. Expert Reviews In Molecular Medicine 2019, 21: e1. PMID: 30862324, DOI: 10.1017/erm.2018.6.Peer-Reviewed Original ResearchConceptsDistinct host environmentsBlood mealHaematophagous vectorsVertebrate animalsVertebrate hostsMosquito-Borne VirusesHuman diseasesNaive mosquitoesHost environmentMosquito tissuesNext blood mealInfected hostVector factorsMosquitoesPathogenic virusesHostVirus reservoirVirus survivalRecent studiesAetiological agentVirusTissueMealDiseaseGenetic Determinants of the Re-Emergence of Arboviral Diseases
Ketkar H, Herman D, Wang P. Genetic Determinants of the Re-Emergence of Arboviral Diseases. Viruses 2019, 11: 150. PMID: 30759739, PMCID: PMC6410223, DOI: 10.3390/v11020150.Peer-Reviewed Original ResearchConceptsViral genetic determinantsPublic health threatGenetic determinantsZika virusViral transmissionInfectious diseasesArboviral diseasesWest NileHealth threatYellow feverDiseaseViral fitnessViral geneticsVector competenceInternational travelVirusMosquitoesGlobal climate changeMosquito populationsFeverHost
2018
A Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses
Wu P, Sun P, Nie K, Zhu Y, Shi M, Xiao C, Liu H, Liu Q, Zhao T, Chen X, Zhou H, Wang P, Cheng G. A Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses. Cell Host & Microbe 2018, 25: 101-112.e5. PMID: 30595552, DOI: 10.1016/j.chom.2018.11.004.Peer-Reviewed Original ResearchConceptsArboviral infectionsCommensal bacteriumGut bacteriaDengue virus infectionGut commensal bacteriumCultivable gut bacteriaAedes aegypti mosquitoesVirus infectionViral disseminationAntibiotic depletionIntestinal tractOral introductionGut microbiomeGut epitheliumInfectionMembrane-bound mucinsHuman virusesAegypti mosquitoesHematophagous vectorsVector competenceArbovirusesField mosquitoesSerratia marcescensMosquitoesVirus
2015
Mosquito Defense Strategies against Viral Infection
Cheng G, Liu Y, Wang P, Xiao X. Mosquito Defense Strategies against Viral Infection. Trends In Parasitology 2015, 32: 177-186. PMID: 26626596, PMCID: PMC4767563, DOI: 10.1016/j.pt.2015.09.009.Peer-Reviewed Original ResearchConceptsViral infectionMosquito antiviral immunityEfficient antiviral strategiesPathological sequelaePersistent infectionAntiviral immunityArbovirus infectionViral replicationAntiviral strategiesInfectionMosquito tissuesViral diseasesGlobal healthViral propagationMosquitoesTissueNatural vectorSequelaeSpecific tissuesDiseaseImmunity
2011
An In Vivo Transfection Approach Elucidates a Role for Aedes aegypti Thioester-Containing Proteins in Flaviviral Infection
Cheng G, Liu L, Wang P, Zhang Y, Zhao YO, Colpitts TM, Feitosa F, Anderson JF, Fikrig E. An In Vivo Transfection Approach Elucidates a Role for Aedes aegypti Thioester-Containing Proteins in Flaviviral Infection. PLOS ONE 2011, 6: e22786. PMID: 21818390, PMCID: PMC3144946, DOI: 10.1371/journal.pone.0022786.Peer-Reviewed Original Research