2021
A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host
Yu X, Shan C, Zhu Y, Ma E, Wang J, Wang P, Shi P, Cheng G. A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2113015118. PMID: 34620704, PMCID: PMC8545446, DOI: 10.1073/pnas.2113015118.Peer-Reviewed Original ResearchConceptsEvolutionary adaptationZIKV capsid proteinAsian ZIKV lineageZika virusMammalian hostsZIKV mutantsNS2B-NS3 proteaseStructural proteinsPreferred substrateHuman cellsCapsid proteinInfectious viral particlesMutantsMosquito vectorsZIKV disseminationMillions of infectionsZIKV lineagesProteinViral particlesHigh prevalenceImmunodeficient miceMosquito infectionExplosive outbreaksMosquitoesStable substitutions
2016
Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes
Liu J, Liu Y, Nie K, Du S, Qiu J, Pang X, Wang P, Cheng G. Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes. Nature Microbiology 2016, 1: 16087. PMID: 27562253, PMCID: PMC5003325, DOI: 10.1038/nmicrobiol.2016.87.Peer-Reviewed Original ResearchConceptsNonstructural protein 1Japanese encephalitis virus nonstructural protein 1Dengue virusDENV nonstructural protein 1Flavivirus nonstructural protein 1Lethal DENV challengeNS1 proteinReceptor-deficient miceVirus nonstructural protein 1Flavivirus NS1 proteinAcquisition of virusDENV challengeActive immunizationFlaviviral diseasesImmune barrierHost serumViral transferInfected mammalian hostsViral acquisitionMosquito midgutMiceProtein 1Virus acquisitionImmunizationMosquito vectorsMosquito C-type lectins maintain gut microbiome homeostasis
Pang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology 2016, 1: 16023. PMID: 27170846, PMCID: PMC4861079, DOI: 10.1038/nmicrobiol.2016.23.Peer-Reviewed Original ResearchC-type lectinMammalian host immune systemHost immune systemAntimicrobial peptidesMajor mosquito vectorsCommensal bacteriaEvolutionary interactionsMultiple bacterial strainsSymbiotic bacteriaGut microbiomeGut microbial floraGut microbiome homeostasisFacilitate colonizationImmune systemGut commensal bacteriaMicrobial floraBacterial surfaceMicrobiome homeostasisAntagonistic relationshipBacterial strainsHomeostasisA. aegyptiMicrobiomeHost immune responseMosquito vectorsMosquito C-type lectins maintain gut microbiome homeostasis.
Pang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology 2016, 1: 16023. PMID: 27572642, DOI: 10.1038/nmicrobiol.2016.23.Peer-Reviewed Original ResearchConceptsC-type lectinMammalian host immune systemHost immune systemAntimicrobial peptidesMajor mosquito vectorsCommensal bacteriaEvolutionary interactionsMultiple bacterial strainsSymbiotic bacteriaGut microbiomeGut microbial floraGut microbiome homeostasisFacilitate colonizationImmune systemGut commensal bacteriaMicrobial floraBacterial surfaceMicrobiome homeostasisAntagonistic relationshipBacterial strainsHomeostasisA. aegyptiMicrobiomeHost immune responseMosquito vectors