2021
Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH
Wang M, An Y, Gao L, Dong S, Zhou X, Feng Y, Wang P, Dimopoulos G, Tang H, Wang J. Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH. Cell Reports 2021, 35: 108992. PMID: 33882310, PMCID: PMC8116483, DOI: 10.1016/j.celrep.2021.108992.Peer-Reviewed Original ResearchConceptsPlasmodium infectionGlucose metabolismMalaria parasitesCommensal bacteriumMosquito midgutPlasmodium berghei infectionGut commensal bacteriumBerghei infectionMosquito-microbiota interactionsDietary glucoseInfectionMetabolome changesVector competencePlasmodium gametogenesisVector competencyGlucoseImportant determinantPlasmodiumProliferationMetabolismMosquitoesParasitesAsaia bogorensis
2016
Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes
Liu J, Liu Y, Nie K, Du S, Qiu J, Pang X, Wang P, Cheng G. Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes. Nature Microbiology 2016, 1: 16087. PMID: 27562253, PMCID: PMC5003325, DOI: 10.1038/nmicrobiol.2016.87.Peer-Reviewed Original ResearchConceptsNonstructural protein 1Japanese encephalitis virus nonstructural protein 1Dengue virusDENV nonstructural protein 1Flavivirus nonstructural protein 1Lethal DENV challengeNS1 proteinReceptor-deficient miceVirus nonstructural protein 1Flavivirus NS1 proteinAcquisition of virusDENV challengeActive immunizationFlaviviral diseasesImmune barrierHost serumViral transferInfected mammalian hostsViral acquisitionMosquito midgutMiceProtein 1Virus acquisitionImmunizationMosquito vectors