2018
Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling
Ma J, Ketkar H, Geng T, Lo E, Wang L, Xi J, Sun Q, Zhu Z, Cui Y, Yang L, Wang P. Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling. Frontiers In Microbiology 2018, 9: 1350. PMID: 29988497, PMCID: PMC6026624, DOI: 10.3389/fmicb.2018.01350.Peer-Reviewed Original ResearchMelanoma differentiation-associated protein 5Zika virusImmune responseNon-structural protein 4AReceptor-mediated immune responsesToll-like receptor-mediated immune responsesRe-emerging flavivirusGuillain-Barre syndromeAntiviral immune responseType I interferon inductionHost immune systemI interferon inductionMammalian host immune systemProtein 4AN-terminal caspase activationMolecular mechanismsNeonatal microcephalyZIKV pathogenesisZIKV replicationImmune evasionImmune systemHuman trophoblastsReceptor signalingSubsequent inductionProtein 5
2016
Mosquito C-type lectins maintain gut microbiome homeostasis
Pang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology 2016, 1: 16023. PMID: 27170846, PMCID: PMC4861079, DOI: 10.1038/nmicrobiol.2016.23.Peer-Reviewed Original ResearchC-type lectinMammalian host immune systemHost immune systemAntimicrobial peptidesMajor mosquito vectorsCommensal bacteriaEvolutionary interactionsMultiple bacterial strainsSymbiotic bacteriaGut microbiomeGut microbial floraGut microbiome homeostasisFacilitate colonizationImmune systemGut commensal bacteriaMicrobial floraBacterial surfaceMicrobiome homeostasisAntagonistic relationshipBacterial strainsHomeostasisA. aegyptiMicrobiomeHost immune responseMosquito vectorsMosquito C-type lectins maintain gut microbiome homeostasis.
Pang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology 2016, 1: 16023. PMID: 27572642, DOI: 10.1038/nmicrobiol.2016.23.Peer-Reviewed Original ResearchConceptsC-type lectinMammalian host immune systemHost immune systemAntimicrobial peptidesMajor mosquito vectorsCommensal bacteriaEvolutionary interactionsMultiple bacterial strainsSymbiotic bacteriaGut microbiomeGut microbial floraGut microbiome homeostasisFacilitate colonizationImmune systemGut commensal bacteriaMicrobial floraBacterial surfaceMicrobiome homeostasisAntagonistic relationshipBacterial strainsHomeostasisA. aegyptiMicrobiomeHost immune responseMosquito vectors