2021
Interaction of Viruses with the Insect Intestine
Ma E, Zhu Y, Liu Z, Wei T, Wang P, Cheng G. Interaction of Viruses with the Insect Intestine. Annual Review Of Virology 2021, 8: 1-17. PMID: 33872516, DOI: 10.1146/annurev-virology-091919-100543.Peer-Reviewed Original ResearchConceptsSymbiotic microorganismsCell-intrinsic antiviral immunityIntrinsic antiviral immunityInsect's intestinal tractVirus-encoded componentsInsect herbivoresFoliage feedingInsect intestineHematophagous insectsPeritrophic matrixIntestinal tractInsectsBlood feedingInteraction of virusVirus invasionIntricate roleAntiviral immunityViral invasionMicroorganismsConstant threatImmunological barrierInvasionUnderlying mechanismHerbivoresNutritional status
2017
Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system
Zhu Y, Zhang R, Zhang B, Zhao T, Wang P, Liang G, Cheng G. Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system. Nature Communications 2017, 8: 1262. PMID: 29093445, PMCID: PMC5665997, DOI: 10.1038/s41467-017-01244-6.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsArbovirusesBloodBunyamwera virusCulexDengue VirusEncephalitis Virus, CaliforniaEncephalitis Virus, JapaneseGABA-A Receptor AntagonistsGamma-Aminobutyric AcidHumansImmunity, InnateMosquito VectorsReceptors, GABA-ARNA, Double-StrandedSemliki forest virusSignal TransductionSindbis VirusVirus ReplicationConceptsGABAergic systemArboviral infectionsArbovirus replicationInfection of mosquitoesAntiviral innate immunityIngestion of bloodBlood protein digestionBlood mealGABA signalingBlood meal acquisitionGABAergic pathwayGABAA receptorsInnate immunityOral introductionGlutamic acidHematophagous insectsInfectionHuman virusesVirus acquisitionSpecific inhibitorGABAProtein digestionCommon mechanismHematophagous natureActivation