2022
Neighboring mutation‐mediated enhancement of dengue virus infectivity and spread
Chen L, Zhang X, Guo X, Peng W, Zhu Y, Wang Z, Yu X, Shi H, Li Y, Zhang L, Wang L, Wang P, Cheng G. Neighboring mutation‐mediated enhancement of dengue virus infectivity and spread. EMBO Reports 2022, 23: embr202255671. PMID: 36197120, PMCID: PMC9638853, DOI: 10.15252/embr.202255671.Peer-Reviewed Original Research
2015
A Neuron-Specific Antiviral Mechanism Prevents Lethal Flaviviral Infection of Mosquitoes
Xiao X, Zhang R, Pang X, Liang G, Wang P, Cheng G. A Neuron-Specific Antiviral Mechanism Prevents Lethal Flaviviral Infection of Mosquitoes. PLOS Pathogens 2015, 11: e1004848. PMID: 25915054, PMCID: PMC4411065, DOI: 10.1371/journal.ppat.1004848.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsAntiviral AgentsApoptosisBrainCell LineCell MembraneDengue VirusDrosophila melanogasterDrosophila ProteinsEncephalitis Virus, JapaneseFemaleHost-Pathogen InteractionsHumansInsect ProteinsNerve Tissue ProteinsNeuronsPhylogenyProtein Interaction Domains and MotifsRecombinant ProteinsViral Envelope ProteinsVirus InternalizationConceptsMosquito nervous systemCentral nervous systemJapanese encephalitis virusNervous systemFlaviviral infectionsDengue virusSindbis virusAntiviral mechanismMembrane targetingDramatic pathologyPlasma membraneAnti-flavivirus activityMosquito cellsSurface envelope proteinMosquito lifespanNatural vectorCulex pipiensHuman viral diseasesNeural cellsFlavivirus infectionEnvelope proteinFunctional blockadeNeural apoptosisMosquito behaviorViral infection