2019
The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers
Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F. The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cell Host & Microbe 2019, 26: 369-384.e8. PMID: 31513772, DOI: 10.1016/j.chom.2019.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAnimalsAntiviral AgentsChromosomal Proteins, Non-HistoneDNA Topoisomerases, Type IDNA VirusesHEK293 CellsHeLa CellsHerpesvirus 1, HumanHeterogeneous-Nuclear Ribonucleoprotein UHost-Pathogen InteractionsHumansImmunity, InnateInterferon Regulatory Factor-3Interferon Regulatory Factor-7MiceNuclear Matrix-Associated ProteinsProtein Serine-Threonine KinasesReceptors, Pattern RecognitionRNA VirusesRNA, Double-StrandedRNA, ViralVirusesConceptsImmune gene transcriptionViral RNAViral RNA sensorsChromatin remodelingTrigger innate immune responsesSuper enhancersGene transcriptionExtranuclear localizationRNA virusesInnate immune responseAntiviral genesDsRNA sensorsRNA sensorsViral dsRNAAntiviral stateAntiviral responseType I IFNDsRNAVSV infectionRobust antiviral responseRNAEnhancerI IFNImmune responseHSV-1Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA Expression
Zhou B, Qi F, Wu F, Nie H, Song Y, Shao L, Han J, Wu Z, Saiyin H, Wei G, Wang P, Ni T, Qian F. Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA Expression. MBio 2019, 10: 10.1128/mbio.00937-19. PMID: 31363026, PMCID: PMC6667616, DOI: 10.1128/mbio.00937-19.Peer-Reviewed Original ResearchConceptsAntiviral immune responseImmune responseInnate immune responseNF-κB subunitsExpression of RelADeficient miceI interferonAntiviral responseVirus-induced cytokine productionHost genome instabilityEndogenous retrovirusesNF-κB signalingType I interferonRNA virus infectionViral RNA mimicViral loadCytokine productionViral challengeVirus infectionLong noncoding RNADeleterious roleRelA expressionViral replicationViral sensorsReduced expression
2011
ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro
Dai J, Pan W, Wang P. ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro. Virology Journal 2011, 8: 468. PMID: 21992229, PMCID: PMC3215395, DOI: 10.1186/1743-422x-8-468.Peer-Reviewed Original ResearchConceptsWest Nile virusNon-infected cellsWNV infectionViral infectionWest Nile virus infectionWest Nile meningoencephalitisInterferon beta 1Type I interferonCellular antiviral responseVirus infectionI interferonAntiviral responseFlaviviridae familyRAW264.7 cellsDENVInfectionConclusionsThese findingsBeta 1Protein ISGylationGene 15SOCS3 siRNANile virusCausative agentExact roleISG15