2021
Interaction of Viruses with the Insect Intestine
Ma E, Zhu Y, Liu Z, Wei T, Wang P, Cheng G. Interaction of Viruses with the Insect Intestine. Annual Review Of Virology 2021, 8: 1-17. PMID: 33872516, DOI: 10.1146/annurev-virology-091919-100543.Peer-Reviewed Original ResearchConceptsSymbiotic microorganismsCell-intrinsic antiviral immunityIntrinsic antiviral immunityInsect's intestinal tractVirus-encoded componentsInsect herbivoresFoliage feedingInsect intestineHematophagous insectsPeritrophic matrixIntestinal tractInsectsBlood feedingInteraction of virusVirus invasionIntricate roleAntiviral immunityViral invasionMicroorganismsConstant threatImmunological barrierInvasionUnderlying mechanismHerbivoresNutritional status
2017
An essential role of PI3K in the control of West Nile virus infection
Wang L, Yang L, Fikrig E, Wang P. An essential role of PI3K in the control of West Nile virus infection. Scientific Reports 2017, 7: 3724. PMID: 28623344, PMCID: PMC5473900, DOI: 10.1038/s41598-017-03912-5.Peer-Reviewed Original ResearchConceptsWest Nile virus infectionPI3K inhibitorsPI3KVirus infectionImmune responseK inhibitorsType I IFN responseAntiviral immune responseI IFN responseCatalytic subunit p110δTNF-α protein productionPrimary mouse macrophagesFlaviviral infectionsAntiviral immunityIFN responseViral titersClass I PI3KAntiviral roleMRNA expressionPI3K activityIFNProtein expressionInfectionMouse macrophagesCell proliferation
2015
Mosquito Defense Strategies against Viral Infection
Cheng G, Liu Y, Wang P, Xiao X. Mosquito Defense Strategies against Viral Infection. Trends In Parasitology 2015, 32: 177-186. PMID: 26626596, PMCID: PMC4767563, DOI: 10.1016/j.pt.2015.09.009.Peer-Reviewed Original ResearchConceptsViral infectionMosquito antiviral immunityEfficient antiviral strategiesPathological sequelaePersistent infectionAntiviral immunityArbovirus infectionViral replicationAntiviral strategiesInfectionMosquito tissuesViral diseasesGlobal healthViral propagationMosquitoesTissueNatural vectorSequelaeSpecific tissuesDiseaseImmunity