2024
A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses
Yang Y, Treger R, Hernandez-Bird J, Lu P, Mao T, Iwasaki A. A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses. Science Immunology 2024, 9: eadd6608. PMID: 39514636, DOI: 10.1126/sciimmunol.add6608.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, ViralB-LymphocytesEndogenous RetrovirusesImmunoglobulin MMiceMice, Inbred C57BLPolysaccharidesConceptsB-1 cellsB cell-deficient miceEndogenous retrovirusesEnveloped virusesNatural IgM antibodiesGermline-encoded antibodiesNaive miceInnate antiviral mechanismsGenetic invadersB cellsVertebrate genomesNatural antibody repertoireRepertoire profilingSurface antigensInfectious endogenous retrovirusIgM antibodiesSelf-proteinsComplement pathwayAntibody repertoireAntibodiesMiceRetrovirusesVirusSensor stimulationGlycoprotein
2013
MicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation
Kang S, Liu W, Lu P, Jin H, Lim H, Shepherd J, Fremgen D, Verdin E, Oldstone M, Qi H, Teijaro J, Xiao C. MicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation. Nature Immunology 2013, 14: 849-857. PMID: 23812097, PMCID: PMC3740954, DOI: 10.1038/ni.2648.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell DifferentiationFlow CytometryGerminal CenterImmunity, HumoralImmunohistochemistryInducible T-Cell Co-Stimulator ProteinLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroRNAsNuclear ProteinsPhosphatidylinositol 3-KinasesPhosphoprotein PhosphatasesSignal TransductionSpecific Pathogen-Free OrganismsT-Lymphocytes, Helper-Inducer