Actin/α-Actinin-Dependent Transport of AMPA Receptors in Dendritic Spines: Role of the PDZ-LIM Protein RIL
Schulz TW, Nakagawa T, Licznerski P, Pawlak V, Kolleker A, Rozov A, Kim J, Dittgen T, Köhr G, Sheng M, Seeburg PH, Osten P. Actin/α-Actinin-Dependent Transport of AMPA Receptors in Dendritic Spines: Role of the PDZ-LIM Protein RIL. Journal Of Neuroscience 2004, 24: 8584-8594. PMID: 15456832, PMCID: PMC6729893, DOI: 10.1523/jneurosci.2100-04.2004.Peer-Reviewed Original ResearchConceptsAMPA receptorsDendritic spinesLIM domain-containing proteinsDomain-containing proteinsActin-dependent mannerCultured neuronsPostsynaptic density fractionSynaptic AMPA receptorsLIM domainsPDZ domainProtein complexesActin cytoskeletonC-terminal peptideNovel regulationHeterologous cellsReceptor transportRILsExcitatory transmissionForebrain synaptosomesMiniature EPSCsSynaptic accumulationRat forebrainSynaptic sitesSynaptic surfaceReceptorsPostsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development
Komai S, Licznerski P, Cetin A, Waters J, Denk W, Brecht M, Osten P. Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development. Nature Neuroscience 2006, 9: 1125-1133. PMID: 16921372, DOI: 10.1038/nn1752.Peer-Reviewed Original ResearchConceptsSomatodendritic excitabilityExperience-dependent developmentLayer 2/3 pyramidal neuronsCortical networksSensory responsesRat somatosensory cortexNormal cortical developmentCortical sensory responsesDevelopmental strengtheningPostsynaptic excitabilityPyramidal neuronsSomatosensory cortexCortical neuronsBarrel cortexPostsynaptic neuronsCortical developmentSensory cortexSensory pathwaysSensory responsivenessSynaptic strengthExcitabilitySensory deprivationCortexNeuronsVivo recordings