2000
G1 kinases and transforming growth factor-β; signaling are associated with a growth pattern switch in diabetes-induced renal growth
Huang H, Preisig P. G1 kinases and transforming growth factor-β; signaling are associated with a growth pattern switch in diabetes-induced renal growth. Kidney International 2000, 58: 162-172. PMID: 10886561, DOI: 10.1046/j.1523-1755.2000.00151.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCDC2-CDC28 KinasesCyclin ECyclin-Dependent Kinase 2Cyclin-Dependent Kinase 4Cyclin-Dependent KinasesDiabetes Mellitus, ExperimentalDiabetic NephropathiesDNA-Binding ProteinsG1 PhaseHyperplasiaHypertrophyKidney Tubules, ProximalMaleProtein Serine-Threonine KinasesProto-Oncogene ProteinsRatsRats, Sprague-DawleyReceptors, Transforming Growth Factor betaSignal TransductionSmad2 ProteinSmad4 ProteinTrans-ActivatorsTransforming Growth Factor betaConceptsReceptor II expressionCyclin E kinase activityReceptor expressionRenal growthGrowth factor beta receptor expressionTGF-beta receptor II expressionBaseline levelsProximal tubule cell growthTGF-beta receptor expressionBody weight ratioCdk2/cyclin E kinase activityCdk2/cyclin E complexesCyclin DRenal proximal tubulesDiabetes mellitusDiabetic ratsTGF-beta signalingDiabetic stateCyclin E complexGrowth patternDay 2Proximal tubulesDay 4Day 10Tubule growth
1999
Size does matter: Will knockout of p21WAF1/CIP1 save the kidney by limiting compensatory renal growth?
Al-Awqati Q, Preisig P. Size does matter: Will knockout of p21WAF1/CIP1 save the kidney by limiting compensatory renal growth? Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 10551-10553. PMID: 10485857, PMCID: PMC33735, DOI: 10.1073/pnas.96.19.10551.Peer-Reviewed Original Research
1997
Media acidification inhibits TGF beta-mediated growth suppression in cultured rabbit proximal tubule cells.
Tovbin D, Franch HA, Alpern RJ, Preisig PA. Media acidification inhibits TGF beta-mediated growth suppression in cultured rabbit proximal tubule cells. Proceedings Of The Association Of American Physicians 1997, 109: 572-9. PMID: 9394419.Peer-Reviewed Original ResearchConceptsDirect antiproliferative effectRabbit proximal tubule cellsProximal tubule cellsAntiproliferative effectsGrowth-suppressive effectsMetabolic acidosisCultured rabbit proximal tubule cellsTubule cellsChronic metabolic acidosisInhibits cell cycle progressionRenal functionRenal growthMitogen-stimulated cellsRenal epithelial cellsProgressive lossHyperplasiaHypertrophyCell cycle progressionEpithelial cellsPrimary culturesPRB phosphorylationAcidosisEGF-induced phosphorylationGrowth suppressionCycle progression
1995
Renal epithelial cell hyperplasia and hypertrophy.
Preisig P, Franch H. Renal epithelial cell hyperplasia and hypertrophy. Seminars In Nephrology 1995, 15: 327-40. PMID: 7569412.Peer-Reviewed Original ResearchConceptsCell cycleNumber of proteinsCell hypertrophyRenal epithelial cellsDNA replicationProtein degradationCell protein contentCell growthGrowth responseCascade of eventsEpithelial cell hyperplasiaMitogenic stimuliIndependent mechanismsForm of hypertrophyEpithelial cellsSequential eventsLysosomal enzymesCurrent understandingPathological processesCell hyperplasiaProtein contentCellsKey roleEpithelial cell hypertrophyRate of growth