1992
Luminal flow rate regulates proximal tubule H-HCO3 transporters
Preisig P. Luminal flow rate regulates proximal tubule H-HCO3 transporters. American Journal Of Physiology 1992, 262: f47-f54. PMID: 1310229, DOI: 10.1152/ajprenal.1992.262.1.f47.Peer-Reviewed Original ResearchConceptsLuminal flow rateLuminal perfusateNa-H antiporter activityProximal tubule acidificationProgressive increaseRate-dependent changesNa-H antiporterTubule acidificationVivo microperfusionH secretionLuminal amilorideAcid loadSecretory activityAlkali loadPerfusateSensitive indexSymporter activityDisulfonic acidAntiporter activityMinBase transportActivityMicroperfusionInitial rateSecretion
1991
Increased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy.
Preisig PA, Alpern RJ. Increased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy. The Journal Of General Physiology 1991, 97: 195-217. PMID: 1849958, PMCID: PMC2216475, DOI: 10.1085/jgp.97.2.195.Peer-Reviewed Original ResearchConceptsHyperfiltration groupChronic hyperfiltrationNa/H antiporterKidney weightCell hypertrophyHigher glomerular filtration rateNa/H antiporter activityH antiporterGlomerular filtration rateVivo microperfused rat proximal tubuleCell pHRat proximal tubuleSymporter activityFiltration rateProximal tubulesUltrafiltrate-like solutionHyperfiltrationSteady-state cell pHProtein feedingPeritubular perfusateDietary proteinParallel increaseUninephrectomyHypertrophyCell acidification